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HAF2 histone acetyltransferase of the TAFII250 family 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821437, updated on 18-Sep-2024

Summary

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Official Symbol
HAF2
Official Full Name
histone acetyltransferase of the TAFII250 family 2
Primary source
TAIR:AT3G19040
Locus tag
AT3G19040
See related
Araport:AT3G19040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
histone acetyltransferase of the TAFII250 family 2; TAF1; TAF1B; TBP-ASSOCIATED FACTOR 1; TBP-ASSOCIATED FACTOR 1B
Summary
Encodes a protein similar to TATA-binding protein-associated factor TAF1 (a.k.a. TAFII250) with histone acetyltransferase activity. It is required in integrating light signals to regulate gene expression and growth.
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Genomic context

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See HAF2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
18
Sequence:
Chromosome: 3; NC_003074.8 (6567021..6575613, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene transcription initiation factor TFIID subunit 1b-like protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene phragmoplast orienting kinesin 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The HAF2 protein shapes histone acetylation levels of PRR5 and LUX loci in Arabidopsis. Lee K, et al. Planta, 2018 Aug. PMID 29789923
  2. Arabidopsis HAF2 gene encoding TATA-binding protein (TBP)-associated factor TAF1, is required to integrate light signals to regulate gene expression and growth. Bertrand C, et al. J Biol Chem, 2005 Jan 14. PMID 15525647
  3. Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to genotoxic stress and viability of the male gametophyte. Waterworth WM, et al. Plant J, 2015 Nov. PMID 26358508, Free PMC Article
  4. Arabidopsis GCN5, HD1, and TAF1/HAF2 interact to regulate histone acetylation required for light-responsive gene expression. Benhamed M, et al. Plant Cell, 2006 Nov. PMID 17085686, Free PMC Article
  5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The midday-activated HAF2 protein stimulates H3 acetylation (H3ac) deposition at the PRR5 and LUX loci, contributing to establishment of the raising phase.
    Title: The HAF2 protein shapes histone acetylation levels of PRR5 and LUX loci in Arabidopsis.
  2. A specific role for TAF1 in plant DNA repair processes and in plant resistance to genotoxic stress.TAF1 interaction with MRE11 is mediated by the C-terminal bromodomain of TAF1.
    Title: Arabidopsis TAF1 is an MRE11-interacting protein required for resistance to genotoxic stress and viability of the male gametophyte.
  3. These results suggest that acetylation of specific histone Lys residues, regulated by GCN5, TAF1, and HD1, is required for light-regulated gene expression.
    Title: Arabidopsis GCN5, HD1, and TAF1/HAF2 interact to regulate histone acetylation required for light-responsive gene expression.
  4. the Arabidopsis HAF2 gene functions as a coactivator capable of integrating light signals and acetylating histones to activate light-induced gene transcription [HAF2]
    Title: Arabidopsis HAF2 gene encoding TATA-binding protein (TBP)-associated factor TAF1, is required to integrate light signals to regulate gene expression and growth.
Submit: New GeneRIF Correction

General gene information

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NM_112790.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone acetyltransferase of the TAFII250 family 2
NP_188534.2
  • histone acetyltransferase of the TAFII250 family 2 (HAF2); FUNCTIONS IN: histone acetyltransferase activity, transcription cofactor activity, DNA binding; INVOLVED IN: histone acetylation, response to light stimulus; LOCATED IN: membrane, transcription factor TFIID complex; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), Bromodomain, conserved site (InterPro:IPR018359), Bromodomain (InterPro:IPR001487); BEST Arabidopsis thaliana protein match is: HAC13 protein (HAC13) (TAIR:AT1G32750.1); Has 14836 Blast hits to 8275 proteins in 670 species: Archae - 0; Bacteria - 64; Metazoa - 6564; Fungi - 2006; Plants - 2354; Viruses - 152; Other Eukaryotes - 3696 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    6567021..6575613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001338377.1 → NP_001327580.1  histone acetyltransferase of the TAFII250 family 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VFF6, A0A1I9LSR7

  2. NM_112790.3 → NP_188534.2  histone acetyltransferase of the TAFII250 family 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188534.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6PUA2, Q9LJ62
    UniProtKB/TrEMBL
    A0A178VFF6
    Conserved Domains (5) summary
    smart00213
    Location:574 → 644
    UBQ; Ubiquitin homologues
    pfam12157
    Location:491 → 1052
    DUF3591; Protein of unknown function (DUF3591)
    pfam15452
    Location:1352 → 1464
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    cl00155
    Location:574 → 646
    UBQ; Ubiquitin-like proteins
    cl02556
    Location:1665 → 1778
    Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PUA2.1

Gene LinkOut

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