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NBS1 nijmegen breakage syndrome 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821254, updated on 18-Sep-2024

Summary

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Official Symbol
NBS1
Official Full Name
nijmegen breakage syndrome 1
Primary source
TAIR:AT3G02680
Locus tag
AT3G02680
See related
Araport:AT3G02680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATNBS1; F16B3.31; F16B3_31; nijmegen breakage syndrome 1
Summary
DNA repair and meiotic recombination protein, component of MRE11 complex with RAD50 and MRE11
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Genomic context

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See NBS1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Sequence:
Chromosome: 3; NC_003074.8 (576308..579562)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Glycine-rich protein family Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nodulin MtN21 /EamA-like transporter family protein Neighboring gene NC domain-containing protein-like protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NBS1 acts in concert with telomerase and plays a profound role in plant telomere renewal.
    Title: NBS1 plays a synergistic role with telomerase in the maintenance of telomeres in Arabidopsis thaliana.
  2. results suggest a novel role for AtNBS1 that is independent of AtATM-mediated signaling and functions in the very early stages of meiosis
    Title: NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_111136.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to ionizing radiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homologous chromosome pairing at meiosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within reciprocal meiotic recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Mre11 complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
nijmegen breakage syndrome 1
NP_186917.2
  • nijmegen breakage syndrome 1 (NBS1); CONTAINS InterPro DOMAIN/s: SMAD/FHA domain (InterPro:IPR008984), Forkhead-associated (FHA) domain (InterPro:IPR000253); Has 164 Blast hits to 161 proteins in 63 species: Archae - 0; Bacteria - 2; Metazoa - 112; Fungi - 0; Plants - 40; Viruses - 0; Other Eukaryotes - 10 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    576308..579562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111136.3 → NP_186917.2  nijmegen breakage syndrome 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_186917.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1YEB0, Q0H8D7, Q9M874
    UniProtKB/TrEMBL
    A0A178VFZ6
    Conserved Domains (3) summary
    COG1716
    Location:24 → 148
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:2 → 124
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam08599
    Location:467 → 522
    Nbs1_C; DNA damage repair protein Nbs1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0H8D7.1

Gene LinkOut

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