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DRH1 DEAD box RNA helicase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821116, updated on 18-Sep-2024

Summary

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Official Symbol
DRH1
Official Full Name
DEAD box RNA helicase 1
Primary source
TAIR:AT3G01540
Locus tag
AT3G01540
See related
Araport:AT3G01540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA DEAD BOX RNA HELICASE 1; ATDRH1; DEAD box RNA helicase 1; F4P13.9; F4P13_9; RNA HELICASE DRH1
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Genomic context

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See DRH1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Sequence:
Chromosome: 3; NC_003074.8 (212518..216736, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Adenine nucleotide alpha hydrolases-like superfamily protein Neighboring gene myb domain protein 57 Neighboring gene phosphoenolpyruvate (pep)/phosphate translocator 2 Neighboring gene proline-rich receptor-like kinase, putative (DUF1421) Neighboring gene Oleosin family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a DEAD box ATPase/RNA helicase protein of Arabidopsis thaliana. Okanami M, et al. Nucleic Acids Res, 1998 Jun 1. PMID 9592148, Free PMC Article
  2. Nucleocytoplasmic trafficking is essential for BAK1- and BKK1-mediated cell-death control. Du J, et al. Plant J, 2016 Feb. PMID 26775605
  3. Loss of INCREASED SIZE EXCLUSION LIMIT (ISE)1 or ISE2 increases the formation of secondary plasmodesmata. Burch-Smith TM, et al. Curr Biol, 2010 Jun 8. PMID 20434343, Free PMC Article
  4. Loss of the plant DEAD-box protein ISE1 leads to defective mitochondria and increased cell-to-cell transport via plasmodesmata. Stonebloom S, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805190, Free PMC Article
  5. Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing. Palm D, et al. Nucleic Acids Res, 2019 Feb 28. PMID 30576513, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A DEAD-box RNA helicase, DRH1, was identified in the same protein complex as SBB1 via a proteomic approach. The drh1 mutation also rescues the cell-death symptoms of bak1-3 bkk1-1.
    Title: Nucleocytoplasmic trafficking is essential for BAK1- and BKK1-mediated cell-death control.
  2. Data show that silencing of ISE1 and ISE2 phenocopies ise1 and ise2 mutant embryos: when wild-type ISE1 and ISE2 functions are lost, de novo production of plasmodesmata occurs, leading to increased intercellular transport.
    Title: Loss of INCREASED SIZE EXCLUSION LIMIT (ISE)1 or ISE2 increases the formation of secondary plasmodesmata.
  3. Data show that ISE1 encodes a putative plant-specific DEAD-box RNA helicase that localizes specifically to mitochondria.
    Title: Loss of the plant DEAD-box protein ISE1 leads to defective mitochondria and increased cell-to-cell transport via plasmodesmata.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001035542.1
NM_111020.3
NM_180161.2
NM_202477.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DEAD box RNA helicase 1
NP_001030619.1
  • DEAD box RNA helicase 1 (DRH1); FUNCTIONS IN: ATPase activity, ATP-dependent RNA helicase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), WW/Rsp5/WWP (InterPro:IPR001202), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEAD box RNA helicase family protein (TAIR:AT5G14610.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_566141.1
  • DEAD box RNA helicase 1 (DRH1); FUNCTIONS IN: ATPase activity, ATP-dependent RNA helicase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), WW/Rsp5/WWP (InterPro:IPR001202), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEAD box RNA helicase family protein (TAIR:AT5G14610.2); Has 49839 Blast hits to 48969 proteins in 3110 species: Archae - 949; Bacteria - 26028; Metazoa - 6650; Fungi - 4984; Plants - 2792; Viruses - 23; Other Eukaryotes - 8413 (source: NCBI BLink).
NP_850492.1
  • DEAD box RNA helicase 1 (DRH1); FUNCTIONS IN: ATPase activity, ATP-dependent RNA helicase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), WW/Rsp5/WWP (InterPro:IPR001202), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEAD box RNA helicase family protein (TAIR:AT5G14610.2); Has 50187 Blast hits to 49315 proteins in 3135 species: Archae - 949; Bacteria - 26432; Metazoa - 6592; Fungi - 4988; Plants - 2789; Viruses - 23; Other Eukaryotes - 8414 (source: NCBI BLink).
NP_974206.1
  • DEAD box RNA helicase 1 (DRH1); FUNCTIONS IN: ATPase activity, ATP-dependent RNA helicase activity; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RNA helicase, ATP-dependent, DEAD-box, conserved site (InterPro:IPR000629), RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), WW/Rsp5/WWP (InterPro:IPR001202), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEAD box RNA helicase family protein (TAIR:AT5G14610.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    212518..216736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001035542.1 → NP_001030619.1  DEAD box RNA helicase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030619.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64430, Q8H136, Q8W4F5, Q93WJ3
    UniProtKB/TrEMBL
    A0A5S9X899, A0A654F363
    Conserved Domains (2) summary
    PTZ00110
    Location:83 → 549
    PTZ00110; helicase; Provisional
    pfam00397
    Location:19 → 49
    WW; WW domain

  2. NM_180161.2 → NP_850492.1  DEAD box RNA helicase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850492.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64430, Q8H136, Q8W4F5, Q93WJ3
    UniProtKB/TrEMBL
    A0A5S9X899, A0A654F363
    Conserved Domains (2) summary
    PTZ00110
    Location:83 → 549
    PTZ00110; helicase; Provisional
    pfam00397
    Location:19 → 49
    WW; WW domain

  3. NM_111020.3 → NP_566141.1  DEAD box RNA helicase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566141.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9X899
    Conserved Domains (4) summary
    cd00079
    Location:377 → 505
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:160 → 364
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    PTZ00110
    Location:83 → 549
    PTZ00110; helicase; Provisional
    pfam00397
    Location:19 → 49
    WW; WW domain

  4. NM_202477.2 → NP_974206.1  DEAD box RNA helicase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64430, Q8H136, Q8W4F5, Q93WJ3
    UniProtKB/TrEMBL
    A0A5S9X899, A0A654F363
    Conserved Domains (2) summary
    PTZ00110
    Location:83 → 549
    PTZ00110; helicase; Provisional
    pfam00397
    Location:19 → 49
    WW; WW domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8H136.2

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