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TRX-M4 thioredoxin M-type 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820775, updated on 18-Sep-2024

Summary

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Official Symbol
TRX-M4
Official Full Name
thioredoxin M-type 4
Primary source
TAIR:AT3G15360
Locus tag
AT3G15360
See related
Araport:AT3G15360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA MYOSIN 4; ARABIDOPSIS THIOREDOXIN M-TYPE 4; ATHM4; ATM4; MJK13.20; thioredoxin M-type 4
Summary
encodes a prokaryotic thioredoxin
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Genomic context

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See TRX-M4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
2
Sequence:
Chromosome: 3; NC_003074.8 (5188241..5189836)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme 25 Neighboring gene phosphopantothenoylcysteine decarboxylase subunit Neighboring gene expansin 12 Neighboring gene Plasma-membrane choline transporter family protein Neighboring gene silencing defective 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thioredoxin m4 controls photosynthetic alternative electron pathways in Arabidopsis. Courteille A, et al. Plant Physiol, 2013 Jan. PMID 23151348, Free PMC Article
  2. Distinct electron transfer from ferredoxin-thioredoxin reductase to multiple thioredoxin isoforms in chloroplasts. Yoshida K, et al. Biochem J, 2017 Apr 4. PMID 28246333
  3. M-type thioredoxins are involved in the xanthophyll cycle and proton motive force to alter NPQ under low-light conditions in Arabidopsis. Da Q, et al. Plant Cell Rep, 2018 Feb. PMID 29080907
  4. Evidence for a role of chloroplastic m-type thioredoxins in the biogenesis of photosystem II in Arabidopsis. Wang P, et al. Plant Physiol, 2013 Dec. PMID 24151299, Free PMC Article
  5. M-Type Thioredoxins Regulate the PGR5/PGRL1-Dependent Pathway by Forming a Disulfide-Linked Complex with PGRL1. Okegawa Y, et al. Plant Cell, 2020 Dec. PMID 33037145, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. M-Type Thioredoxins Regulate the PGR5/PGRL1-Dependent Pathway by Forming a Disulfide-Linked Complex with PGRL1.
    Title: M-Type Thioredoxins Regulate the PGR5/PGRL1-Dependent Pathway by Forming a Disulfide-Linked Complex with PGRL1.
  2. Data show that the m-type thioredoxins TRX-m1, TRX-m2, and TRX-m4 (TRX-ms) interact with the xanthophyll cycle enzyme zeaxanthin epoxidase (ZE) and are required for maintaining the redox-dependent stabilization of ZE.
    Title: M-type thioredoxins are involved in the xanthophyll cycle and proton motive force to alter NPQ under low-light conditions in Arabidopsis.
  3. Data suggest that all 10 chloroplast Trx (thioredoxin) isoforms are commonly reduced by Ftr (ferredoxin- thioredoxin reductase), however, significantly different efficiencies are evident in the kinetics of electron transfer; the reduction rate of Trx-m4 was higher than that of other Trx-m isoforms.
    Title: Distinct electron transfer from ferredoxin-thioredoxin reductase to multiple thioredoxin isoforms in chloroplasts.
  4. These results suggest an important role for TRX m1, TRX m2, and TRX m4 proteins in the biogenesis of photosystem II.
    Title: Evidence for a role of chloroplastic m-type thioredoxins in the biogenesis of photosystem II in Arabidopsis.
  5. NADH dehydrogenase-like complex activity is increased in an Arabidopsis mutant lacking TRXm4.
    Title: Thioredoxin m4 controls photosynthetic alternative electron pathways in Arabidopsis.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_112404.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of carbohydrate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in chloroplast thylakoid membrane HDA PubMed 
located_in cytosol HDA PubMed 
located_in plant-type cell wall HDA PubMed 
located_in thylakoid HDA PubMed 

General protein information

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Preferred Names
thioredoxin M-type 4
NP_188155.1
  • thioredoxin M-type 4 (TRX-M4); FUNCTIONS IN: enzyme activator activity; INVOLVED IN: response to oxidative stress, positive regulation of catalytic activity; LOCATED IN: thylakoid, chloroplast thylakoid membrane, cell wall, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin (InterPro:IPR005746), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin M-type 1 (TAIR:AT1G03680.1); Has 22907 Blast hits to 21478 proteins in 3001 species: Archae - 325; Bacteria - 11943; Metazoa - 2959; Fungi - 1292; Plants - 2075; Viruses - 15; Other Eukaryotes - 4298 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    5188241..5189836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112404.5 → NP_188155.1  thioredoxin M-type 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188155.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WUS9, Q9LDP6, Q9SEU6
    UniProtKB/TrEMBL
    A0A178VJ83, A0A5S9XCK4, A0A7G2ELV3
    Conserved Domains (1) summary
    TIGR01068
    Location:91 → 191
    thioredoxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SEU6.2

Gene LinkOut

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