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PPC3 phosphoenolpyruvate carboxylase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820723, updated on 18-Sep-2024

Summary

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Official Symbol
PPC3
Official Full Name
phosphoenolpyruvate carboxylase 3
Primary source
TAIR:AT3G14940
Locus tag
AT3G14940
See related
Araport:AT3G14940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPPC3; phosphoenolpyruvate carboxylase 3
Summary
Encodes a cytosolic phosphoenolpyruvate carboxylase (PEPC) that has activity when expressed in E.coli. Its mRNA is most abundantly expressed in roots and siliques. PPC3 belongs to the plant-type PEPC family. It can form an enzymatically active complex with a castor bean ortholog of PPC4, which encodes a bacterial-type PEPC.
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Genomic context

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See PPC3 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (5025184..5029886)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Rab3 GTPase-activating protein non-catalytic subunit Neighboring gene Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A protein Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene tetratricopetide-repeat thioredoxin-like 2 Neighboring gene Galactosyltransferase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and biochemical characterization of citrate binding to AtPPC3, a plant-type phosphoenolpyruvate carboxylase from Arabidopsis thaliana. Connell MB, et al. J Struct Biol, 2018 Dec. PMID 30419358
  2. Phosphoenolpyruvate carboxylase (PEPC) and PEPC-kinase (PEPC-k) isoenzymes in Arabidopsis thaliana: role in control and abiotic stress conditions. Feria AB, et al. Planta, 2016 Oct. PMID 27306451
  3. Bacterial- and plant-type phosphoenolpyruvate carboxylase polypeptides interact in the hetero-oligomeric Class-2 PEPC complex of developing castor oil seeds. Gennidakis S, et al. Plant J, 2007 Dec. PMID 17894783
  4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
  5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Citrate functions as a mixed (allosteric) inhibitor as it reduced phosphoenolpyruvate carboxylase 3 (AtPPC3)'s Vmax while increasing Km(PEP) values.
    Title: Structural and biochemical characterization of citrate binding to AtPPC3, a plant-type phosphoenolpyruvate carboxylase from Arabidopsis thaliana.
  2. Phosphoenolpyruvate carboxylase (PEPC) activity was decreased in shoots and roots of ppc2 and ppc3 mutants, and phosphate starvation increased the expression of all PEPC and phosphoenolpyruvate carboxylase kinase genes in shoots, but only PPC3 and PPCK2 in roots
    Title: Phosphoenolpyruvate carboxylase (PEPC) and PEPC-kinase (PEPC-k) isoenzymes in Arabidopsis thaliana: role in control and abiotic stress conditions.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001338141.1
NM_112356.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphoenolpyruvate carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
phosphoenolpyruvate carboxylase 3
NP_188112.1
  • phosphoenolpyruvate carboxylase 3 (PPC3); FUNCTIONS IN: phosphoenolpyruvate carboxylase activity; INVOLVED IN: response to salt stress, tricarboxylic acid cycle; LOCATED IN: cytosol; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Phosphoenolpyruvate carboxylase, active site (InterPro:IPR018129), Phosphoenolpyruvate carboxylase (InterPro:IPR001449), Phosphoenolpyruvate carboxylase, C-terminal region (InterPro:IPR021135); BEST Arabidopsis thaliana protein match is: phosphoenolpyruvate carboxylase 1 (TAIR:AT1G53310.3); Has 6864 Blast hits to 6805 proteins in 1910 species: Archae - 27; Bacteria - 2657; Metazoa - 5; Fungi - 0; Plants - 1758; Viruses - 0; Other Eukaryotes - 2417 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    5025184..5029886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112356.4 → NP_188112.1  phosphoenolpyruvate carboxylase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188112.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81357, Q0WTJ7, Q84VW9
    UniProtKB/TrEMBL
    A0A178VET0, A0A5S9XC87
    Conserved Domains (2) summary
    COG2352
    Location:25 → 968
    Ppc; Phosphoenolpyruvate carboxylase [Energy production and conversion]
    pfam00311
    Location:164 → 968
    PEPcase; Phosphoenolpyruvate carboxylase

  2. NM_001338141.1 → NP_001326778.1  phosphoenolpyruvate carboxylase 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81357, Q0WTJ7, Q84VW9
    UniProtKB/TrEMBL
    A0A178VET0, A0A5S9XC87
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84VW9.2

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