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Leucine-rich repeat transmembrane protein kinase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820713, updated on 18-Sep-2024

Summary

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Official Full Name
Leucine-rich repeat transmembrane protein kinase
Primary source
TAIR:AT3G14840
Locus tag
AT3G14840
See related
Araport:AT3G14840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
LIK1; LysM RLK1-interacting kinase 1
Summary
Encodes LRR-RLK protein that is localized to the plasma membrane and is involved in regulation of plant innate immunity to microbes. LIK1 is phosphorylated by CERK1, a kinase involved in chitin perception.
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Genomic context

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Location:
chromosome: 3
Exon count:
24
Sequence:
Chromosome: 3; NC_003074.8 (4988008..4994109)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene epstein-barr nuclear antigen Neighboring gene TRICHOME BIREFRINGENCE-LIKE 41 Neighboring gene tRNA-Cys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A brassinosteroid-signaling kinase interacts with multiple receptor-like kinases in Arabidopsis. Xu P, et al. Mol Plant, 2014 Feb. PMID 24051702, Free PMC Article
  2. Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana. Lampugnani ER, et al. PLoS One, 2024. PMID 38358988, Free PMC Article
  3. LIK1, a CERK1-interacting kinase, regulates plant immune responses in Arabidopsis. Le MH, et al. PLoS One, 2014. PMID 25036661, Free PMC Article
  4. An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Smakowska-Luzan E, et al. Nature, 2018 Jan 18. PMID 29320478, Free PMC Article
  5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIK1 directly interacts with CERK1 and regulates MAMP-triggered innate immunity. [LIK1]
    Title: LIK1, a CERK1-interacting kinase, regulates plant immune responses in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_112345.7
NM_112346.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within jasmonic acid and ethylene-dependent systemic resistance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
Leucine-rich repeat transmembrane protein kinase
NP_188102.5
  • Leucine-rich repeat transmembrane protein kinase; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Malectin/receptor-like protein kinase (InterPro:IPR021720), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat (InterPro:IPR001611), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat transmembrane protein kinase (TAIR:AT1G53420.1); Has 185540 Blast hits to 134573 proteins in 4786 species: Archae - 122; Bacteria - 17971; Metazoa - 51218; Fungi - 10628; Plants - 83318; Viruses - 446; Other Eukaryotes - 21837 (source: NCBI BLink).
NP_566494.1
  • Leucine-rich repeat transmembrane protein kinase; FUNCTIONS IN: protein kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; BEST Arabidopsis thaliana protein match is: Leucine-rich repeat transmembrane protein kinase (TAIR:AT1G07650.1); Has 83 Blast hits to 83 proteins in 11 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 83; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    4988008..4994109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112345.7 → NP_188102.5  Leucine-rich repeat transmembrane protein kinase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188102.5

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0LGN2, Q94EW5, Q9LH71
    UniProtKB/TrEMBL
    A0A178VFX9, A0A654F792
    Conserved Domains (4) summary
    PLN00113
    Location:12 → 944
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    cd14066
    Location:678 → 945
    STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
    sd00033
    Location:113 → 135
    LRR_RI; leucine-rich repeat [structural motif]
    pfam11721
    Location:403 → 590
    Malectin; Di-glucose binding within endoplasmic reticulum

  2. NM_112346.4 → NP_566494.1  Leucine-rich repeat transmembrane protein kinase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566494.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C0LGN2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C0LGN2.1

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