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AL2 alfin-like 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820290, updated on 18-Sep-2024

Summary

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Official Symbol
AL2
Official Full Name
alfin-like 2
Primary source
TAIR:AT3G11200
Locus tag
AT3G11200
See related
Araport:AT3G11200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
alfin-like 2; F11B9.12
Summary
Encodes a member of the Alfin1-like family of nuclear-localized PHD (plant homeodomain) domain containing proteins. All AL proteins except AL3 bind to di- or trimethylated histone H3 (H3K4me3/2). Members of this family include: AT5G05610 (AL1), AT3G11200 (AL2), AT3G42790 (AL3), AT5G26210 (AL4), AT5G20510 (AL5), AT2G02470 (AL6), AT1G14510 (AL7).
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Genomic context

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See AL2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (3507996..3510658, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase 7 Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene SGNH hydrolase-type esterase superfamily protein Neighboring gene Paxneb protein-like protein Neighboring gene Yippee family putative zinc-binding protein Neighboring gene arginine-tRNA protein transferase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch. Peng L, et al. J Mol Biol, 2018 Oct 19. PMID 30176245
  2. Arabidopsis AL PHD-PRC1 complexes promote seed germination through H3K4me3-to-H3K27me3 chromatin state switch in repression of seed developmental genes. Molitor AM, et al. PLoS Genet, 2014 Jan. PMID 24465219, Free PMC Article
  3. Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers. Lee WY, et al. Plant J, 2009 May. PMID 19154204
  4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
  5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_111955.3
NM_202551.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
alfin-like 2
NP_187729.1
  • alfin-like 2 (AL2); CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Protein of unknown function DUF3594 (InterPro:IPR021998), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: alfin-like 1 (TAIR:AT5G05610.2); Has 1527 Blast hits to 1482 proteins in 179 species: Archae - 0; Bacteria - 0; Metazoa - 758; Fungi - 235; Plants - 458; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).
NP_974280.1
  • alfin-like 2 (AL2); CONTAINS InterPro DOMAIN/s: Zinc finger, PHD-type, conserved site (InterPro:IPR019786), Protein of unknown function DUF3594 (InterPro:IPR021998), Zinc finger, PHD-type (InterPro:IPR001965), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Zinc finger, PHD-finger (InterPro:IPR019787); BEST Arabidopsis thaliana protein match is: alfin-like 1 (TAIR:AT5G05610.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    3507996..3510658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111955.3 → NP_187729.1  alfin-like 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187729.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SRM4
    UniProtKB/TrEMBL
    A0A178VG14, A0A5S9XAZ9
    Conserved Domains (2) summary
    cd15613
    Location:192 → 242
    PHD_AL_plant; PHD finger found in plant Alfin1-like (AL) proteins
    pfam12165
    Location:13 → 138
    Alfin

  2. NM_202551.1 → NP_974280.1  alfin-like 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974280.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4J673
    Conserved Domains (2) summary
    cd15613
    Location:179 → 229
    PHD_AL_plant; PHD finger found in plant Alfin1-like (AL) proteins
    pfam12165
    Location:32 → 125
    DUF3594; Domain of unknown function (DUF3594)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SRM4.1

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