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LSF2 dual specificity protein phosphatase (DsPTP1) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820265, updated on 18-Sep-2024

Summary

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Official Symbol
LSF2
Official Full Name
dual specificity protein phosphatase (DsPTP1) family protein
Primary source
TAIR:AT3G10940
Locus tag
AT3G10940
See related
Araport:AT3G10940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
LIKE SEX4 2
Summary
Encodes a protein with a predicted dual-specificity phosphatase domain, similar to the glucan phosphorylases SEX4 and LSF1, however, it lacks the carbohydrate binding domain present in those proteins. Has phosphoglucan phosphatase activity. It binds to starch and specifically hydrolyzes phosphate from the C3-position.
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Genomic context

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See LSF2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (3422034..3423455, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene manganese superoxide dismutase 1 Neighboring gene uncharacterized protein Neighboring gene Zinc-binding ribosomal protein family protein Neighboring gene AZA-guanine resistant1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The LIKE SEX FOUR2 regulates root development by modulating reactive oxygen species homeostasis in Arabidopsis. Zhao P, et al. Sci Rep, 2016 Jun 28. PMID 27349915, Free PMC Article
  2. Structure of the Arabidopsis glucan phosphatase like sex four2 reveals a unique mechanism for starch dephosphorylation. Meekins DA, et al. Plant Cell, 2013 Jun. PMID 23832589, Free PMC Article
  3. The phosphoglucan phosphatase like sex Four2 dephosphorylates starch at the C3-position in Arabidopsis. Santelia D, et al. Plant Cell, 2011 Nov. PMID 22100529, Free PMC Article
  4. Plant α-glucan phosphatases SEX4 and LSF2 display different affinity for amylopectin and amylose. Wilkens C, et al. FEBS Lett, 2016 Jan. PMID 26763114
  5. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings indicated the novel function of LSF2 that controls ROS homeostasis to regulate root development.
    Title: The LIKE SEX FOUR2 regulates root development by modulating reactive oxygen species homeostasis in Arabidopsis.
  2. Data suggest LSF2 has 50-fold lower affinity for amylopectin compared to SEX4, indicating LSF2 more easily dissociates from starch granule; SEX4 prefers amylopectin; LSF2 has highest affinity toward amylose with 8-fold higher affinity compared to SEX4.
    Title: Plant α-glucan phosphatases SEX4 and LSF2 display different affinity for amylopectin and amylose.
  3. Data indicate two additional glucan binding sites were identified within the core glucan phosphatase like sex four2 (LSF2) phosphatase domain.
    Title: Structure of the Arabidopsis glucan phosphatase like sex four2 reveals a unique mechanism for starch dephosphorylation.
  4. LSF2 is involved in starch metabolism in Arabidopsis chloroplasts
    Title: The phosphoglucan phosphatase like sex Four2 dephosphorylates starch at the C3-position in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_111931.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables carbohydrate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables starch binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sugar-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in starch catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in starch catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase (DsPTP1) family protein
NP_566383.1
  • dual specificity protein phosphatase (DsPTP1) family protein; FUNCTIONS IN: phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation, dephosphorylation; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase (DsPTP1) family protein (TAIR:AT3G52180.2); Has 897 Blast hits to 897 proteins in 122 species: Archae - 6; Bacteria - 12; Metazoa - 607; Fungi - 18; Plants - 142; Viruses - 11; Other Eukaryotes - 101 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    3422034..3423455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111931.3 → NP_566383.1  dual specificity protein phosphatase (DsPTP1) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566383.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LBS6, Q9SRK5
    UniProtKB/TrEMBL
    A0A178V8E2, A0A654FGH8
    Conserved Domains (1) summary
    cd14526
    Location:91 → 238
    DSP_laforin-like; dual specificity phosphatase domain of laforin and similar domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SRK5.1

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