U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MSD1 manganese superoxide dismutase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820263, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
MSD1
Official Full Name
manganese superoxide dismutase 1
Primary source
TAIR:AT3G10920
Locus tag
AT3G10920
See related
Araport:AT3G10920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS MANGANESE SUPEROXIDE DISMUTASE 1; ATMSD1; AtSOD1; manganese superoxide dismutase 1; MANGANESE SUPEROXIDE DISMUTASE 1; MATERNAL EFFECT EMBRYO ARREST 33; MEE33; superoxide dismutase 1
Summary
manganese superoxide dismutase (MSD1)
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MSD1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Sequence:
Chromosome: 3; NC_003074.8 (3417940..3419892)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene Reticulon family protein Neighboring gene uncharacterized protein Neighboring gene dual specificity protein phosphatase (DsPTP1) family protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An anchoring complex recruits katanin for microtubule severing at the plant cortical nucleation sites. Yagi N, et al. Nat Commun, 2021 Jun 17. PMID 34140499, Free PMC Article
  2. Expression, purification and crystallization of MnSOD from Arabidopsis thaliana. Marques AT, et al. Acta Crystallogr F Struct Biol Commun, 2014 May. PMID 24817734, Free PMC Article
  3. oiwa, a female gametophytic mutant impaired in a mitochondrial manganese-superoxide dismutase, reveals crucial roles for reactive oxygen species during embryo sac development and fertilization in Arabidopsis. Martin MV, et al. Plant Cell, 2013 May. PMID 23653473, Free PMC Article
  4. Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis. Morgan MJ, et al. Plant Physiol, 2008 May. PMID 18337490, Free PMC Article
  5. Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration. Holzmeister C, et al. J Exp Bot, 2015 Feb. PMID 25428993, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An anchoring complex recruits katanin for microtubule severing at the plant cortical nucleation sites.
    Title: An anchoring complex recruits katanin for microtubule severing at the plant cortical nucleation sites.
  2. Peroxynitrite inhibited mitochondrial manganese superoxide dismutase (SOD1; MSD1), peroxisomal copper/zinc SOD3 (CSD3), and chloroplastic iron SOD3 (FSD3), but no other SODs. MSD1 was inhibited by up to 90% but CSD3 and FSD3 only by a maximum of 30%.
    Title: Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration.
  3. Manganese superoxide dismutase from Arabidopsis was expressed, purified and crystallized.
    Title: Expression, purification and crystallization of MnSOD from Arabidopsis thaliana.
  4. Data indicate that Mn-superoxide dismutase MSD1 activity seems critical for maintaining reactive oxygen species (ROS) localization and important for embryo sac patterning.
    Title: oiwa, a female gametophytic mutant impaired in a mitochondrial manganese-superoxide dismutase, reveals crucial roles for reactive oxygen species during embryo sac development and fertilization in Arabidopsis.
  5. Reduced MnSOD affects mitochondrial redox balance and plant growth.
    Title: Decrease in manganese superoxide dismutase leads to reduced root growth and affects tricarboxylic acid cycle flux and mitochondrial redox homeostasis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

NM_001035593.2
NM_111929.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables copper ion binding HDA PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within removal of superoxide radicals IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
manganese superoxide dismutase 1
NP_001030670.1
  • manganese superoxide dismutase 1 (MSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding, metal ion binding; INVOLVED IN: response to zinc ion, response to salt stress, defense response to bacterium, removal of superoxide radicals, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Iron/manganese superoxide dismutase family protein (TAIR:AT3G56350.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_187703.1
  • manganese superoxide dismutase 1 (MSD1); FUNCTIONS IN: superoxide dismutase activity, copper ion binding, metal ion binding; INVOLVED IN: response to zinc ion, response to salt stress, defense response to bacterium, removal of superoxide radicals, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Manganese/iron superoxide dismutase, N-terminal (InterPro:IPR019831), Manganese/iron superoxide dismutase (InterPro:IPR001189), Manganese/iron superoxide dismutase, C-terminal (InterPro:IPR019832), Manganese/iron superoxide dismutase, binding site (InterPro:IPR019833); BEST Arabidopsis thaliana protein match is: Iron/manganese superoxide dismutase family protein (TAIR:AT3G56350.1); Has 11404 Blast hits to 11403 proteins in 3385 species: Archae - 194; Bacteria - 8096; Metazoa - 447; Fungi - 710; Plants - 427; Viruses - 1; Other Eukaryotes - 1529 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    3417940..3419892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111929.4 → NP_187703.1  manganese superoxide dismutase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187703.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81235, Q8LEP0, Q9SRK3
    UniProtKB/TrEMBL
    A0A178VDR9, A0A5S9XB82
    Conserved Domains (3) summary
    PLN02471
    Location:1 → 231
    PLN02471; superoxide dismutase [Mn]
    pfam00081
    Location:30 → 111
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:121 → 224
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

  2. NM_001035593.2 → NP_001030670.1  manganese superoxide dismutase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030670.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VDR9, A0A5S9XB82, F4J504
    Conserved Domains (3) summary
    PLN02471
    Location:1 → 230
    PLN02471; superoxide dismutase [Mn]
    pfam00081
    Location:30 → 111
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:121 → 223
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O81235.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.