U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ROXY1 Thioredoxin superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820200, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ROXY1
Official Full Name
Thioredoxin superfamily protein
Primary source
TAIR:AT3G02000
Locus tag
AT3G02000
See related
Araport:AT3G02000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F1C9.22
Summary
Roxy1 encodes a glutaredoxin belonging to a subgroup specific to higher plants. It is required for proper petal initiation and organogenesis. It is likely to function in the temporal and spatial expression regulation of AGAMOUS in the first and second whorl. It's function is dependent on the Cysteine 49 residue and its nuclear localization. ROXY1 interacts in vitro and in vivo with members of the TGA family of transcription factors (e.g. TGA2, TGA3, TGA7 and PAN).
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ROXY1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
1
Sequence:
Chromosome: 3; NC_003074.8 (332275..333072, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene WRKY DNA-binding protein 45 Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene ACT domain repeat 6 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene aspartate kinase 3 Neighboring gene transferase Neighboring gene senescence-related gene 3

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dual-color 3D-dSTORM colocalization and quantification of ROXY1 and RNAPII variants throughout the transcription cycle in root meristem nuclei. Maß L, et al. Plant J, 2020 Dec. PMID 32896918
  2. ROXY1, a member of the plant glutaredoxin family, is required for petal development in Arabidopsis thaliana. Xing S, et al. Development, 2005 Apr. PMID 15728668
  3. ROXY1 and ROXY2, two Arabidopsis glutaredoxin genes, are required for anther development. Xing S, et al. Plant J, 2008 Mar. PMID 18036205
  4. The ROXY1 C-terminal L**LL motif is essential for the interaction with TGA transcription factors. Li S, et al. Plant Physiol, 2011 Dec. PMID 21960138, Free PMC Article
  5. Arabidopsis basic leucine-zipper transcription factors TGA9 and TGA10 interact with floral glutaredoxins ROXY1 and ROXY2 and are redundantly required for anther development. Murmu J, et al. Plant Physiol, 2010 Nov. PMID 20805327, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual-color 3D-dSTORM colocalization and quantification of ROXY1 and RNAPII variants throughout the transcription cycle in root meristem nuclei.
    Title: Dual-color 3D-dSTORM colocalization and quantification of ROXY1 and RNAPII variants throughout the transcription cycle in root meristem nuclei.
  2. TGA9 and TGA10 expression overlaps with ROXY1/2 in developing anthers.
    Title: Arabidopsis basic leucine-zipper transcription factors TGA9 and TGA10 interact with floral glutaredoxins ROXY1 and ROXY2 and are redundantly required for anther development.
  3. ROXY1/TGA protein interactions in the nucleus have a role in petal development.
    Title: Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is required for petal development in Arabidopsis thaliana.
  4. Two CC-type glutaredoxins ROXY1 and ROXY2 together control anther development in Arabidopsis thaliana.[ROXY2]
    Title: ROXY1 and ROXY2, two Arabidopsis glutaredoxin genes, are required for anther development.
  5. ROXY1 is involved in flower development, probably by mediating post-translational modifications of target proteins (ROXY1)
    Title: ROXY1, a member of the plant glutaredoxin family, is required for petal development in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_111066.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables disulfide oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anther development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within petal development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within petal formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stamen morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Thioredoxin superfamily protein
NP_186849.1
  • ROXY1; CONTAINS InterPro DOMAIN/s: Glutaredoxin-like, plant II (InterPro:IPR011905), Thioredoxin fold (InterPro:IPR012335), Glutaredoxin (InterPro:IPR002109), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: Thioredoxin superfamily protein (TAIR:AT5G14070.1); Has 1149 Blast hits to 1147 proteins in 188 species: Archae - 0; Bacteria - 38; Metazoa - 213; Fungi - 109; Plants - 748; Viruses - 0; Other Eukaryotes - 41 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    332275..333072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111066.4 → NP_186849.1  Thioredoxin superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_186849.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q96305, Q9S7X8
    UniProtKB/TrEMBL
    A0A178VBU2, A0A5S9X8V7
    Conserved Domains (1) summary
    TIGR02189
    Location:35 → 136
    GlrX-like_plant; Glutaredoxin-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96305.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools