P4H2 P4H isoform 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: P4H2
Official Full Name: P4H isoform 2
Primary source: TAIR:AT3G06300
Locus tag: AT3G06300
See related: Araport:AT3G06300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT-P4H-2; F24P17.24; F24P17_24; P4H isoform 2; PROLYL 4-HYDROXYLASE; prolyl 4-hydroxylase 2
Summary: Encodes a prolyl-4 hydroxylase that can hydroxylate poly(L-proline)and other proline rich peptides, including those with sequences corresponding to those in arabinogalactan proteins and extensins.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

P4H5,P4H2 and P4H13 are pivotal for root hair tip growth.
Title: Complex regulation of prolyl-4-hydroxylases impacts root hair expansion.
molecular cloning and characterization of second prolyl 4-hydroxylase in Arabidopsis[At-P4H-2]
Title: Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity.

Submit: New GeneRIF Correction

NM_111505.4

Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables procollagen-proline 4-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within root hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in Golgi cis cisterna	HDA more info	PubMed
located_in endosome	HDA more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in trans-Golgi network	HDA more info	PubMed

NP_566279.1

P4H isoform 2 (AT-P4H-2); FUNCTIONS IN: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, procollagen-proline 4-dioxygenase activity; INVOLVED IN: peptidyl-proline hydroxylation to 4-hydroxy-L-proline; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Prolyl 4-hydroxylase, alpha subunit (InterPro:IPR006620), Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123), Metridin-like ShK toxin (InterPro:IPR003582); BEST Arabidopsis thaliana protein match is: 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein (TAIR:AT5G18900.1); Has 2500 Blast hits to 2478 proteins in 341 species: Archae - 0; Bacteria - 386; Metazoa - 1038; Fungi - 78; Plants - 408; Viruses - 17; Other Eukaryotes - 573 (source: NCBI BLink).