MKP2 MAPK phosphatase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MKP2
Official Full Name: MAPK phosphatase 2
Primary source: TAIR:AT3G06110
Locus tag: AT3G06110
See related: Araport:AT3G06110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS MAPK PHOSPHATASE 2; ATMKP2; DSPTP1B; DUAL-SPECIFICITY PROTEIN PHOSPHATASE 1B; F28L1.5; F28L1_5; MAPK phosphatase 2
Summary: Encodes a nuclear-localized MAP kinase phosphatase. Plants with reduced levels of MKP2 transcripts are hypersensitive to ozone and ozone-mediated activation of MPK3 and MPK6 is prolonged in these plants.
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Genomic context

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See MKP2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 5

Sequence:: Chromosome: 3; NC_003074.8 (1843413..1845062)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

silencing promoted early leaf senescence
Title: Gene network analysis and functional studies of senescence-associated genes reveal novel regulators of Arabidopsis leaf senescence.
This study describes the interplay of MAPK and MKP2 phosphatase signaling during cell death responses elicited by host-pathogen interactions.[MKP2]
Title: Regulation of MAPK signaling and cell death by MAPK phosphatase MKP2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001202892.1

Supported by ESTs:

NM_111486.3

Supported by ESTs:

NM_180191.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables MAP kinase phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IC Inferred by Curator more info	PubMed
involved_in negative regulation of plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ozone	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: MAPK phosphatase 2

NP_001189821.1

MAPK phosphatase 2 (MKP2); CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase 1 (TAIR:AT3G23610.2).

NP_566272.1

MAPK phosphatase 2 (MKP2); FUNCTIONS IN: MAP kinase phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; INVOLVED IN: intracellular protein kinase cascade, response to ozone, negative regulation of MAP kinase activity, response to stress; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase 1 (TAIR:AT3G23610.2); Has 4028 Blast hits to 4023 proteins in 348 species: Archae - 21; Bacteria - 87; Metazoa - 2101; Fungi - 442; Plants - 308; Viruses - 204; Other Eukaryotes - 865 (source: NCBI BLink).

NP_850522.1

MAPK phosphatase 2 (MKP2); FUNCTIONS IN: MAP kinase phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; INVOLVED IN: intracellular protein kinase cascade, response to ozone, negative regulation of MAP kinase activity, response to stress; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: dual specificity protein phosphatase 1 (TAIR:AT3G23610.2); Has 4168 Blast hits to 4160 proteins in 377 species: Archae - 19; Bacteria - 125; Metazoa - 2129; Fungi - 477; Plants - 302; Viruses - 229; Other Eukaryotes - 887 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

1843413..1845062

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202892.1 → NP_001189821.1 MAPK phosphatase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189821.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LDW2, Q9M8K7

UniProtKB/TrEMBL

A0A5S9X9K9, A0A654F4I8

Conserved Domains (1) summary

cd14498
Location:26 → 158

DSP; dual-specificity phosphatase domain
NM_180191.3 → NP_850522.1 MAPK phosphatase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850522.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8LDW2, Q9M8K7

UniProtKB/TrEMBL

A0A5S9X9K9, A0A654F4I8

Conserved Domains (1) summary

cd14498
Location:26 → 158

DSP; dual-specificity phosphatase domain
NM_111486.3 → NP_566272.1 MAPK phosphatase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566272.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M8K7

Conserved Domains (1) summary

cd00127
Location:25 → 150

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...