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TSC10A NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819779, updated on 18-Sep-2024

Summary

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Official Symbol
TSC10A
Official Full Name
NAD(P)-binding Rossmann-fold superfamily protein
Primary source
TAIR:AT3G06060
Locus tag
AT3G06060
See related
Araport:AT3G06060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F24F17.4; F24F17_4
Summary
Encodes one of the Arabidopsis proteins (At3g06060/TSC10A and At5g19200/TSC10B) with significant similarity to the yeast 3-ketodihydrosphinganine (3-KDS) reductase, Tsc10p. Both TSC10A and TSC10B are bona fide 3-KDS reductase as shown by complementation experiment in yeast.
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Genomic context

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See TSC10A in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (1827922..1830469, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L12/ ATP-dependent Clp protease adaptor protein ClpS family protein Neighboring gene peroxiredoxin IIF Neighboring gene uncharacterized protein Neighboring gene trichome birefringence-like protein (DUF828) Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana. Chao DY, et al. Plant Cell, 2011 Mar. PMID 21421810, Free PMC Article
  2. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TSC10A encodes a functionally redundant 3-KDS reductase required for sphingolipid synthesis.
    Title: Sphingolipids in the root play an important role in regulating the leaf ionome in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_111481.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 3-dehydrosphinganine reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-dehydrosphinganine reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADPH binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 3-keto-sphinganine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 3-keto-sphinganine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sphingolipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingolipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NAD(P)-binding Rossmann-fold superfamily protein
NP_187257.2
  • NAD(P)-binding Rossmann-fold superfamily protein; FUNCTIONS IN: oxidoreductase activity, binding, catalytic activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT5G19200.1); Has 110611 Blast hits to 110370 proteins in 3576 species: Archae - 917; Bacteria - 74698; Metazoa - 5725; Fungi - 6415; Plants - 2635; Viruses - 0; Other Eukaryotes - 20221 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    1827922..1830469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001337630.1 → NP_001325788.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LMA8, A0A654F5R7

  2. NM_111481.3 → NP_187257.2  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187257.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WRJ2, Q9M7S9
    UniProtKB/TrEMBL
    A0A654F5R7
    Conserved Domains (2) summary
    cd08939
    Location:40 → 273
    KDSR-like_SDR_c; 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR
    pfam00106
    Location:40 → 228
    adh_short; short chain dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0WRJ2.1

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