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TOC64-III translocon at the outer membrane of chloroplasts 64-III [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819660, updated on 18-Sep-2024

Summary

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Official Symbol
TOC64-III
Official Full Name
translocon at the outer membrane of chloroplasts 64-III
Primary source
TAIR:AT3G17970
Locus tag
AT3G17970
See related
Araport:AT3G17970
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AT3G17960; atToc64-III; translocon at the outer membrane of chloroplasts 64-III
Summary
Integral chloroplast outer membrane protein. Belongs to one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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Genomic context

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See TOC64-III in Genome Data Viewer
Location:
chromosome: 3
Exon count:
13
Sequence:
Chromosome: 3; NC_003074.8 (6147906..6152082)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Galactose mutarotase-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene WUSCHEL related homeobox 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ligand recognition by the TPR domain of the import factor Toc64 from Arabidopsis thaliana. Panigrahi R, et al. PLoS One, 2013. PMID 24391770, Free PMC Article
  2. Evolutionarily evolved discriminators in the 3-TPR domain of the Toc64 family involved in protein translocation at the outer membrane of chloroplasts and mitochondria. Mirus O, et al. J Mol Model, 2009 Aug. PMID 19198901
  3. Toc64--a preprotein-receptor at the outer membrane with bipartide function. Qbadou S, et al. J Mol Biol, 2007 Apr 13. PMID 17306301
  4. Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 from Arabidopsis thaliana. Panigrahi R, et al. J Mol Recognit, 2014 Jun. PMID 24700626
  5. Toc33 and Toc64-III cooperate in precursor protein import into the chloroplasts of Arabidopsis thaliana. Sommer M, et al. Plant Cell Environ, 2013 May. PMID 23131143

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our findings suggest that the TPR domain from AtToc64 has higher affinity towards C-terminal residues of Hsp70.
    Title: Exploring ligand recognition, selectivity and dynamics of TPR domains of chloroplast Toc64 and mitochondria Om64 from Arabidopsis thaliana.
  2. mode of recognition of the C-termini of Hsp70 and Hsp90 chaperones by the Tetratricopeptide Repeat (TPR) domain of the chloroplast import receptor Toc64
    Title: Ligand recognition by the TPR domain of the import factor Toc64 from Arabidopsis thaliana.
  3. Toc64 participates in chloroplast protein import and cooperates in part with Toc33.
    Title: Toc33 and Toc64-III cooperate in precursor protein import into the chloroplasts of Arabidopsis thaliana.
  4. Data built homology models of the 3-TPR domain of chloroplastic Toc64 from different species.
    Title: Evolutionarily evolved discriminators in the 3-TPR domain of the Toc64 family involved in protein translocation at the outer membrane of chloroplasts and mitochondria.
  5. Toc64 is involved in preprotein translocation across the outer envelope at both sites of the membrane.
    Title: Toc64--a preprotein-receptor at the outer membrane with bipartide function.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001338317.1
NM_112678.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast envelope HDA PubMed 
located_in chloroplast outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in plastid HDA PubMed 

General protein information

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Preferred Names
translocon at the outer membrane of chloroplasts 64-III
NP_188424.2
  • translocon at the outer membrane of chloroplasts 64-III (TOC64-III); FUNCTIONS IN: binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor; LOCATED IN: integral to chloroplast outer membrane, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Amidase (InterPro:IPR000120), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: translocon at the outer membrane of chloroplasts 64-V (TAIR:AT5G09420.1); Has 32911 Blast hits to 27744 proteins in 2680 species: Archae - 530; Bacteria - 15888; Metazoa - 4120; Fungi - 2515; Plants - 2100; Viruses - 0; Other Eukaryotes - 7758 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    6147906..6152082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112678.4 → NP_188424.2  translocon at the outer membrane of chloroplasts 64-III [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188424.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LVH5
    UniProtKB/TrEMBL
    A0A178V5L5, A0A5S9XD70
    Conserved Domains (3) summary
    TIGR00990
    Location:463 → 588
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:474 → 502
    TPR; TPR repeat [structural motif]
    cl18951
    Location:33 → 451
    Amidase

  2. NM_001338317.1 → NP_001325422.1  translocon at the outer membrane of chloroplasts 64-III [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178V5L5, A0A1I9LL70
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LVH5.1

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