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SWP RNA polymerase II transcription mediator [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819634, updated on 18-Sep-2024

Summary

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Official Symbol
SWP
Official Full Name
RNA polymerase II transcription mediator
Primary source
TAIR:AT3G04740
Locus tag
AT3G04740
See related
Araport:AT3G04740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS MEDIATOR COMPONENTS 14; ATMED14; F7O18.23; F7O18_23; MED14; MEDIATOR COMPONENTS 14; STRUWWELPETER
Summary
encodes a protein with similarities to subunits of the Mediator complex, required for RNA polymerase II recruitment at target promoters in response to specific activators. Lines carrying loss of function mutations in the gene have reduced cell numbers in aerial organs. On the other hand, lines overexpressing the gene have increased number of small cells in clusters, suggesting cell division is more unsynchronized in the overexpressors.Required for expression of CBF-controlled cold-responsive genes. Required for recruitment of the Mediator complex and RNA polymerase II to CBF-controlled cold-responsive genes. Required for expression of some dark-upregulated genes.
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Genomic context

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See SWP in Genome Data Viewer
Location:
chromosome: 3
Exon count:
8
Sequence:
Chromosome: 3; NC_003074.8 (1293798..1300792)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene indoleacetic acid-induced protein 16 Neighboring gene RALF-like 21 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential requirement of MED14/17 recruitment for activation of heat inducible genes. Ohama N, et al. New Phytol, 2021 Mar. PMID 33251584
  2. Cell numbers and leaf development in Arabidopsis: a functional analysis of the STRUWWELPETER gene. Autran D, et al. EMBO J, 2002 Nov 15. PMID 12426376, Free PMC Article
  3. The Arabidopsis Mediator complex subunits MED14/SWP and MED16/SFR6/IEN1 differentially regulate defense gene expression in plant immune responses. Zhang X, et al. Plant J, 2013 Aug. PMID 23607369
  4. PHYTOCHROME-INTERACTING FACTOR 4/HEMERA-mediated thermosensory growth requires the Mediator subunit MED14. Bajracharya A, et al. Plant Physiol, 2022 Nov 28. PMID 36063057, Free PMC Article
  5. Mediator Subunits MED16, MED14, and MED2 Are Required for Activation of ABRE-Dependent Transcription in Arabidopsis. Lee M, et al. Front Plant Sci, 2021. PMID 33777083, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential requirement of MED14/17 recruitment for activation of heat inducible genes.
    Title: Differential requirement of MED14/17 recruitment for activation of heat inducible genes.
  2. Med14 and Med17 emerged as the key components of the Arabidopsis Mediator complex providing important scaffold for the whole complex.
    Title: Interaction map of Arabidopsis Mediator complex expounding its topology.
  3. RNA polymerase II recruitment to CBF-responsive cold-regulated genes requires MED16, MED2, and MED14 subunits.
    Title: The Arabidopsis mediator complex subunits MED16, MED14, and MED2 regulate mediator and RNA polymerase II recruitment to CBF-responsive cold-regulated genes.
  4. The Arabidopsis Mediator complex subunits MED14 and MED16 differentially regulate defense gene expression in plant immune responses.
    Title: The Arabidopsis Mediator complex subunits MED14/SWP and MED16/SFR6/IEN1 differentially regulate defense gene expression in plant immune responses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_111346.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cold acclimation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of thermomorphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of plant organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to temperature stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within systemic acquired resistance IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
RNA polymerase II transcription mediator
NP_187125.1
  • STRUWWELPETER (SWP); FUNCTIONS IN: RNA polymerase II transcription mediator activity; INVOLVED IN: positive regulation of transcription, positive regulation of cell proliferation; LOCATED IN: mediator complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med14 (InterPro:IPR013947); Has 940 Blast hits to 375 proteins in 163 species: Archae - 0; Bacteria - 61; Metazoa - 117; Fungi - 104; Plants - 74; Viruses - 0; Other Eukaryotes - 584 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    1293798..1300792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111346.4 → NP_187125.1  RNA polymerase II transcription mediator [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187125.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SR02
    UniProtKB/TrEMBL
    A0A178VAI6, A0A5S9X9R6, A0A654F9D6
    Conserved Domains (1) summary
    pfam08638
    Location:8 → 198
    Med14; Mediator complex subunit MED14
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SR02.1

Gene LinkOut

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