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THA2 threonine aldolase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819608, updated on 18-Sep-2024

Summary

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Official Symbol
THA2
Official Full Name
threonine aldolase 2
Primary source
TAIR:AT3G04520
Locus tag
AT3G04520
See related
Araport:AT3G04520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
threonine aldolase 2
Summary
Encodes a threonine aldolase, involved in threonine degradation to glycine. Expressed in vascular tissue through out the plant.
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Genomic context

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See THA2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Sequence:
Chromosome: 3; NC_003074.8 (1217174..1219847, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene LIGHT-DEPENDENT SHORT HYPOCOTYLS-like protein (DUF640) Neighboring gene tRNA-Arg Neighboring gene phosphoenolpyruvate carboxylase kinase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two Arabidopsis threonine aldolases are nonredundant and compete with threonine deaminase for a common substrate pool. Joshi V, et al. Plant Cell, 2006 Dec. PMID 17172352, Free PMC Article
  2. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
  3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
  4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

NM_001202878.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables threonine aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within threonine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
threonine aldolase 2
NP_001189807.1
  • threonine aldolase 2 (THA2); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: threonine aldolase 1 (TAIR:AT1G08630.4).
NP_566228.1
  • threonine aldolase 2 (THA2); CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aromatic amino acid beta-eliminating lyase/threonine aldolase (InterPro:IPR001597), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: threonine aldolase 1 (TAIR:AT1G08630.4); Has 4083 Blast hits to 4076 proteins in 1195 species: Archae - 22; Bacteria - 2430; Metazoa - 91; Fungi - 241; Plants - 97; Viruses - 0; Other Eukaryotes - 1202 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    1217174..1219847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111323.4 → NP_566228.1  threonine aldolase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566228.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FPH3, Q9M835
    UniProtKB/TrEMBL
    A0A178VL48, A0A5S9X9C0, A0A654F421
    Conserved Domains (1) summary
    PLN02721
    Location:3 → 355
    PLN02721; threonine aldolase

  2. NM_001337534.1 → NP_001327633.1  threonine aldolase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FPH3, Q9M835
    UniProtKB/TrEMBL
    A0A178VL48, A0A5S9X9C0, A0A654F421
    Conserved Domains (1) summary
    PLN02721
    Location:3 → 355
    PLN02721; threonine aldolase

  3. NM_001202878.1 → NP_001189807.1  threonine aldolase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189807.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VL48, F4J4S1
    Conserved Domains (1) summary
    PLN02721
    Location:3 → 354
    PLN02721; threonine aldolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FPH3.1

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