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ABCC4 multidrug resistance-associated protein 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819392, updated on 18-Sep-2024

Summary

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Official Symbol
ABCC4
Official Full Name
multidrug resistance-associated protein 4
Primary source
TAIR:AT2G47800
Locus tag
AT2G47800
See related
Araport:AT2G47800
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMRP4; ATP-binding cassette C4; EST3; F17A22.19; MRP4; multidrug resistance-associated protein 4
Summary
Encodes a plasma membrane localized ATPase transporter involved in multidrug transport. The expression of this gene is upregulated by herbicide safeners such as benoxacor, fluxofenim and fenclorim.
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Genomic context

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See ABCC4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Sequence:
Chromosome: 2; NC_003071.7 (19574666..19580615)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Rubber elongation factor protein (REF) Neighboring gene TSPO(outer membrane tryptophan-rich sensory protein)-like protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene nuclear factor Y, subunit B5 Neighboring gene arginine-glutamic acid dipeptide repeat protein Neighboring gene Cation efflux family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of AtMRP4, a guard cell plasma membrane ABCC-type ABC transporter, leads to deregulation of stomatal opening and increased drought susceptibility. Klein M, et al. Plant J, 2004 Jul. PMID 15225287
  2. Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line. Pérez-Pineda SI, et al. Ann Hepatol, 2021 Sep-Oct. PMID 33582321
  3. Organization and function of the plant pleiotropic drug resistance ABC transporter family. Crouzet J, et al. FEBS Lett, 2006 Feb 13. PMID 16506311
  4. Mechanical stress induces biotic and abiotic stress responses via a novel cis-element. Walley JW, et al. PLoS Genet, 2007 Oct. PMID 17953483, Free PMC Article
  5. Nematode-induced changes of transporter gene expression in Arabidopsis roots. Hammes UZ, et al. Mol Plant Microbe Interact, 2005 Dec. PMID 16478044

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.
    Title: Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_130347.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ABC-type xenobiotic transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables folic acid transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to nematode HEP PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within stomatal movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasmodesma HDA PubMed 
located_in vacuolar membrane HDA PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
multidrug resistance-associated protein 4
NP_182301.1
  • multidrug resistance-associated protein 4 (MRP4); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, folic acid transporter activity; INVOLVED IN: response to water deprivation, drug transmembrane transport, response to wounding, response to nematode, stomatal movement; LOCATED IN: vacuolar membrane, plasma membrane, vacuole, plant-type vacuole; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), ABC transporter, transmembrane domain, type 1 (InterPro:IPR011527), ABC transporter integral membrane type 1 (InterPro:IPR017940), ABC transporter, transmembrane domain (InterPro:IPR001140), ABC transporter, conserved site (InterPro:IPR017871); BEST Arabidopsis thaliana protein match is: multidrug resistance-associated protein 10 (TAIR:AT3G62700.1); Has 714857 Blast hits to 368077 proteins in 3991 species: Archae - 12925; Bacteria - 579268; Metazoa - 12980; Fungi - 8565; Plants - 6599; Viruses - 19; Other Eukaryotes - 94501 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    19574666..19580615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130347.5 → NP_182301.1  multidrug resistance-associated protein 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_182301.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O24525, Q0WVT4, Q7DM58
    UniProtKB/TrEMBL
    A0A7G2EET4
    Conserved Domains (4) summary
    cd03244
    Location:1272 → 1492
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:641 → 841
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:255 → 1502
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:976 → 1229
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7DM58.2

Gene LinkOut

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