CP12-1 CP12 domain-containing protein 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CP12-1
Official Full Name: CP12 domain-containing protein 1
Primary source: TAIR:AT2G47400
Locus tag: AT2G47400
See related: Araport:AT2G47400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CP12; CP12 domain-containing protein 1; CP12 DOMAIN-CONTAINING PROTEIN 1; T8I13.24
Summary: CP12-1 encodes a small peptide found in the chloroplast stroma. It belongs to the CP12 gene family thought to be involved in the formation of a supramolecular complex with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase (PRK) embedded in the Calvin cycle.
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Genomic context

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See CP12-1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (19446730..19447642)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single cp12-1, cp12-2, and cp12-3 mutants do not develop a severe photosynthetic or growth phenotype. In contrast, reductions of both CP12-1 and CP12-2 transcripts lead to reductions in photosynthetic capacity and to slower growth and reduced seed yield. No clear phenotype for CP12-3 was evident.
Title: Arabidopsis CP12 mutants have reduced levels of phosphoribulokinase and impaired function of the Calvin-Benson cycle.
The shape and structural assembly of the photosynthetic GAPDH-CP12-PRK complex from Arabidopsis thaliana has been presented.
Title: Unravelling the shape and structural assembly of the photosynthetic GAPDH-CP12-PRK complex from Arabidopsis thaliana by small-angle X-ray scattering analysis.
CP12 in oxygen phototrophs needs to be extended beyond light/dark regulation, and include protection of enzymes belonging to Calvine-Benson cycle from oxidative stress.
Title: CP12-mediated protection of Calvin-Benson cycle enzymes from oxidative stress.
All CP12 isoforms formed, in vitro, a supramolecular complex with GAPDH and PRK, with comparable inhibitory effects on both enzyme activities.
Title: In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties.
CP12-1 and CP12-2 expression was detected in the sepals and the style of the flower, while CP12-3 was restricted to the stigma and anthers.
Title: Expression analysis of the Arabidopsis CP12 gene family suggests novel roles for these proteins in roots and floral tissues.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_130308.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nickel cation binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
NOT involved_in cellular response to anoxia	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in cellular response to cold	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in cellular response to heat	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of reductive pentose-phosphate cycle	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sucrose	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast stroma	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	HDA more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CP12 domain-containing protein 1

NP_566100.2

CP12 domain-containing protein 1 (CP12-1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: negative regulation of reductive pentose-phosphate cycle; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function CP12 (InterPro:IPR003823); BEST Arabidopsis thaliana protein match is: CP12 domain-containing protein 2 (TAIR:AT3G62410.1); Has 264 Blast hits to 264 proteins in 70 species: Archae - 0; Bacteria - 128; Metazoa - 0; Fungi - 0; Plants - 120; Viruses - 0; Other Eukaryotes - 16 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

19446730..19447642

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130308.3 → NP_566100.2 CP12 domain-containing protein 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566100.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O22914, Q8RYE5, Q941E3

UniProtKB/TrEMBL

A0A178VSF3, A0A5S9X7T8

Conserved Domains (1) summary

PLN00204
Location:1 → 124

PLN00204; CP12 gene family protein; Provisional