BOR1 HCO3- transporter family [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BOR1
Official Full Name: HCO3- transporter family
Primary source: TAIR:AT2G47160
Locus tag: AT2G47160
See related: Araport:AT2G47160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtBOR1; REQUIRES HIGH BORON 1; T3D7.3
Summary: Boron transporter. Protein accumulates in shoots and roots under conditions of boron deficiency and is degraded within several hours of restoring boron supply. Localized to the plasma membrane under B limitation, and to the cytoplasm after B application before degradation. Protein is transferred via the endosomes to the vacuole for degradation. Localized to the inner plasma membrane domain in the columella, lateral root cap, epidermis, and endodermis in the root tip region, and in the epidermis and endodermis in the elongation zone. Under high-boron is transported to the vacuole for degradation.
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Genomic context

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See BOR1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 12

Sequence:: Chromosome: 2; NC_003071.7 (19357420..19361328, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Bor1 elevator transport cycle is subject to autoinhibition and activation.
Title: The Bor1 elevator transport cycle is subject to autoinhibition and activation.
CPK10 protein kinase regulates Arabidopsis tolerance to boron deficiency through phosphorylation and activation of BOR1 transporter.
Title: CPK10 protein kinase regulates Arabidopsis tolerance to boron deficiency through phosphorylation and activation of BOR1 transporter.
Transfer of stabilising mutations between different secondary active transporter families.
Title: Transfer of stabilising mutations between different secondary active transporter families.
Structural and functional insights into the mechanism of action of plant borate transporters.
Title: Structural and functional insights into the mechanism of action of plant borate transporters.
Transport-coupled ubiquitination of the borate transporter BOR1 for its boron-dependent degradation.
Title: Transport-coupled ubiquitination of the borate transporter BOR1 for its boron-dependent degradation.
Involvement of boron transporter BOR1 in growth under low boron and high nitrate conditions in Arabidopsis thaliana.
Title: Involvement of boron transporter BOR1 in growth under low boron and high nitrate conditions in Arabidopsis thaliana.
Analysis of Endocytosis and Intracellular Trafficking of Boric Acid/Borate Transport Proteins in Arabidopsis.
Title: Analysis of Endocytosis and Intracellular Trafficking of Boric Acid/Borate Transport Proteins in Arabidopsis.
Two mechanisms of post-transcriptional BOR1 regulation, each induced under different Boron concentrations, contribute to the avoidance of Boron toxicity in plants.
Title: Boron-Dependent Translational Suppression of the Borate Exporter BOR1 Contributes to the Avoidance of Boron Toxicity.
Here, we present the 4.1-A resolution crystal structure of Arabidopsis thaliana Bor1. The structure displays a dimeric architecture in which dimerization is mediated by centralized Gate domains. Comparisons with a structure of Band 3 in an outward-open state reveal that the Core domains of Bor1 have rotated inwards to achieve an occluded state.
Title: Structure of Bor1 supports an elevator transport mechanism for SLC4 anion exchangers.
Polar localization of BOR1 is dependent on DRP1-mediated endocytosis.
Title: DRP1-Dependent Endocytosis is Essential for Polar Localization and Boron-Induced Degradation of the Borate Transporter BOR1 in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001084602.2

Supported by ESTs:

NM_180138.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables active borate transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables active borate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables borate efflux transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables solute:inorganic anion antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in borate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within borate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to boron-containing substance levels	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of nutrient	IDA Inferred from Direct Assay more info
involved_in monoatomic anion transport	IEA Inferred from Electronic Annotation more info
involved_in response to boron-containing substance	IDA Inferred from Direct Assay more info	PubMed
involved_in response to boron-containing substance	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in columella	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: HCO3- transporter family

NP_001078071.1

REQUIRES HIGH BORON 1 (BOR1); CONTAINS InterPro DOMAIN/s: Bicarbonate transporter, eukaryotic (InterPro:IPR003020), Bicarbonate transporter, C-terminal (InterPro:IPR011531); BEST Arabidopsis thaliana protein match is: HCO3- transporter family (TAIR:AT3G62270.1); Has 2632 Blast hits to 1400 proteins in 192 species: Archae - 0; Bacteria - 6; Metazoa - 1971; Fungi - 316; Plants - 233; Viruses - 2; Other Eukaryotes - 104 (source: NCBI BLink).

NP_850469.1

REQUIRES HIGH BORON 1 (BOR1); CONTAINS InterPro DOMAIN/s: Bicarbonate transporter, eukaryotic (InterPro:IPR003020), Bicarbonate transporter, C-terminal (InterPro:IPR011531); BEST Arabidopsis thaliana protein match is: HCO3- transporter family (TAIR:AT3G62270.1); Has 2647 Blast hits to 1412 proteins in 196 species: Archae - 0; Bacteria - 8; Metazoa - 1975; Fungi - 323; Plants - 233; Viruses - 2; Other Eukaryotes - 106 (source: NCBI BLink).