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CNGC11 cyclic nucleotide-gated channels [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819252, updated on 18-Sep-2024

Summary

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Official Symbol
CNGC11
Official Full Name
cyclic nucleotide-gated channels
Primary source
TAIR:AT2G46440
Locus tag
AT2G46440
See related
Araport:AT2G46440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCNGC11; cyclic nucleotide-gated channel 11; CYCLIC NUCLEOTIDE-GATED CHANNEL 11; cyclic nucleotide-gated channels; F11C10.13
Summary
Member of Cyclic nucleotide gated channel family. Positive regulator of resistance against avirulent fungal pathogen.
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Genomic context

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See CNGC11 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (19061688..19064937)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene helicase with zinc finger protein Neighboring gene cyclic nucleotide gated channel 3 Neighboring gene cyclic nucleotide-gated channel 12 Neighboring gene OxaA/YidC-like membrane insertion protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High throughput chemical screening supports the involvement of Ca2+ in cyclic nucleotide-gated ion channel-mediated programmed cell death in Arabidopsis. Abdel-Hamid H, et al. Plant Signal Behav, 2011 Nov. PMID 22041991, Free PMC Article
  2. The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca²⁺-dependent physiological responses and act in a synergistic manner. Urquhart W, et al. J Exp Bot, 2011 Jun. PMID 21414958, Free PMC Article
  3. Importance of the alphaC-helix in the cyclic nucleotide binding domain for the stable channel regulation and function of cyclic nucleotide gated ion channels in Arabidopsis. Chin K, et al. J Exp Bot, 2010 May. PMID 20378667, Free PMC Article
  4. The chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 activates multiple pathogen resistance responses. Yoshioka K, et al. Plant Cell, 2006 Mar. PMID 16461580, Free PMC Article
  5. Environmentally sensitive, SA-dependent defense responses in the cpr22 mutant of Arabidopsis. Yoshioka K, et al. Plant J, 2001 May. PMID 11439131

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. residues important for intersubunit interactions of CNGC12 and CNGC11
    Title: A suppressor screen of the chimeric AtCNGC11/12 reveals residues important for intersubunit interactions of cyclic nucleotide-gated ion channels.
  2. AtCNGC11 and 12 mediates a Ca2+ signal that is involved not only in plant immunity, but also in developmental processes such as gravitropic bending and senescence.
    Title: High throughput chemical screening supports the involvement of Ca2+ in cyclic nucleotide-gated ion channel-mediated programmed cell death in Arabidopsis.
  3. AtCNGC11 and 12 gene expression was induced during dark-induced senescence and AtCNGC11 and 12 knockout mutants displayed enhanced chlorophyll loss, which was even more pronounced in the double mutant, also indicating synergistic roles in senescence.
    Title: The cyclic nucleotide-gated channels AtCNGC11 and 12 are involved in multiple Ca²⁺-dependent physiological responses and act in a synergistic manner.
  4. AlphaC-helix in the cyclic nucleotide binding domain is functionally important for CNGC11 and CNGC12.
    Title: Importance of the alphaC-helix in the cyclic nucleotide binding domain for the stable channel regulation and function of cyclic nucleotide gated ion channels in Arabidopsis.
  5. A 3-kb deletion fuses two cyclic nucleotide-gated ion channel (ATCNGC)-encoding genes, ATCNGC11 and ATCNGC12, to generate a novel chimeric gene, ATCNGC11/12.
    Title: The chimeric Arabidopsis CYCLIC NUCLEOTIDE-GATED ION CHANNEL11/12 activates multiple pathogen resistance responses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_130208.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables monoatomic cation channel activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to fungus IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
cyclic nucleotide-gated channels
NP_182167.2
  • cyclic nucleotide-gated channels (CNGC11); FUNCTIONS IN: ion channel activity, cyclic nucleotide binding, calmodulin binding, cation channel activity; INVOLVED IN: response to fungus; LOCATED IN: membrane; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710); BEST Arabidopsis thaliana protein match is: cyclic nucleotide-gated channel 12 (TAIR:AT2G46450.1); Has 2962 Blast hits to 2888 proteins in 221 species: Archae - 0; Bacteria - 24; Metazoa - 1476; Fungi - 2; Plants - 940; Viruses - 0; Other Eukaryotes - 520 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    19061688..19064937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001337191.1 → NP_001325416.1  cyclic nucleotide-gated channels [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B370

  2. NM_130208.4 → NP_182167.2  cyclic nucleotide-gated channels [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_182167.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q682T0, Q9SKD6
    UniProtKB/TrEMBL
    A0A178VR19, A0A5S9X7G7
    Conserved Domains (1) summary
    cd00038
    Location:437 → 564
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SKD6.2

Gene LinkOut

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