CPFTSY signal recognition particle receptor protein, chloroplast (FTSY) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CPFTSY
Official Full Name: signal recognition particle receptor protein, chloroplast (FTSY)
Primary source: TAIR:AT2G45770
Locus tag: AT2G45770
See related: Araport:AT2G45770
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ALPHA SUBUNIT CPFTSY; CHLOROPLAST SRP RECEPTOR HOMOLOG; F4I18.25; FERRIC CHELATE REDUCTASE DEFECTIVE 4; FRD4
Summary: chloroplast SRP receptor homolog, alpha subunit CPFTSY. Required for LHCP integration into isolated thylakoids.
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Genomic context

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See CPFTSY in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 11

Sequence:: Chromosome: 2; NC_003071.7 (18851088..18853741)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cpFtsY membrane-binding motif plays a critical role in the intramolecular communication that regulates cpSRP receptor functions at the membrane.
Title: The membrane-binding motif of the chloroplast signal recognition particle receptor (cpFtsY) regulates GTPase activity.
cpftsY mutants generally exhibit defects in the biogenesis of light-harvesting chlorophyll proteins and other thylakoidal membrane proteins that are less severe than in the alb3 mutants.
Title: Non-identical contributions of two membrane-bound cpSRP components, cpFtsY and Alb3, to thylakoid biogenesis.
the crystal structure of chloroplast FtsY (cpFtsY) at 1.75 A resolution.
Title: The structure of the chloroplast signal recognition particle (SRP) receptor reveals mechanistic details of SRP GTPase activation and a conserved membrane targeting site.
These results highlight intriguing differences between the classical and chloroplast SRP and SRP receptor GTPases, and help explain how the chloroplast SRP pathway can mediate efficient targeting of proteins to the thylakoid membrane.
Title: Efficient interaction between two GTPases allows the chloroplast SRP pathway to bypass the requirement for an SRP RNA.
Mutations within the cpFtsY gene are associated with an inability to induce Fe(III) chelate reductase activity in response to iron deficiency.
Title: Arabidopsis cpFtsY mutants exhibit pleiotropic defects including an inability to increase iron deficiency-inducible root Fe(III) chelate reductase activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_130140.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within photosynthetic electron transport in photosystem II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into chloroplast thylakoid membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thylakoid membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast thylakoid	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: signal recognition particle receptor protein, chloroplast (FTSY)

NP_566056.1

CPFTSY; FUNCTIONS IN: nucleoside-triphosphatase activity, GTP binding, nucleotide binding; INVOLVED IN: protein import into chloroplast thylakoid membrane, protein targeting, thylakoid membrane organization, photosynthetic electron transport in photosystem II; LOCATED IN: chloroplast, signal recognition particle, endoplasmic reticulum targeting, chloroplast thylakoid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), Signal recognition particle, SRP54 subunit, helical bundle (InterPro:IPR013822), Signal recognition particle, SRP54 subunit, GTPase (InterPro:IPR000897), Cell division transporter substrate-binding protein FtsY (InterPro:IPR004390); BEST Arabidopsis thaliana protein match is: chloroplast signal recognition particle 54 kDa subunit (TAIR:AT5G03940.1); Has 16847 Blast hits to 16846 proteins in 2926 species: Archae - 468; Bacteria - 10588; Metazoa - 346; Fungi - 290; Plants - 258; Viruses - 1; Other Eukaryotes - 4896 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18851088..18853741

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130140.3 → NP_566056.1 signal recognition particle receptor protein, chloroplast (FTSY) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566056.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4IH43, O80842, Q9SWS7, Q9XFR1

UniProtKB/TrEMBL

A0A178VSN3, A0A5S9X7C5, A0A654F2A5

Conserved Domains (1) summary

PRK10416
Location:48 → 365

PRK10416; signal recognition particle-docking protein FtsY; Provisional