Hip1r huntingtin interacting protein 1 related [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hip1rprovided by RGD
Official Full Name: huntingtin interacting protein 1 relatedprovided by RGD
Primary source: RGD:621615
See related: EnsemblRapid:ENSRNOG00000001091 AllianceGenome:RGD:621615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including SH3 domain binding activity; phosphatidylinositol phosphate binding activity; and protein dimerization activity. Involved in postsynapse organization. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human HIP1R (huntingtin interacting protein 1 related). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 96.2), Heart (RPKM 82.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (38251085..38279756, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32590164..32618841, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (38024517..38053184, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localization of HIP1r at postsynaptic spines in rat brain suggests a role of HIP1r for vesicle trafficking through interaction with F-actin and working together with huntingtin and HIP1 at the synaptic sites.
Title: Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin adaptor activity	ISO Inferred from Sequence Orthology more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin light chain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in digestive system development	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in membrane organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastric acid secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endocytic zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endocytic zone	IMP Inferred from Mutant Phenotype more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: huntingtin-interacting protein 1-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134763.1 → NP_001128235.1 huntingtin-interacting protein 1-related protein isoform 1

Status: VALIDATED

Source sequence(s)

AB005052, BC169096

UniProtKB/TrEMBL

F1LML7, Q99PW9

Related

ENSRNOP00000029635.5, ENSRNOT00000034264.6

Conserved Domains (5) summary

smart00307
Location:815 → 1013

ILWEQ; I/LWEQ domain

pfam07651
Location:28 → 300

ANTH; ANTH domain

pfam09728
Location:358 → 614

Taxilin; Myosin-like coiled-coil protein

pfam16515
Location:462 → 560

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

cl23720
Location:350 → 468

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_031234.1 → NP_112513.1 huntingtin-interacting protein 1-related protein isoform 2

See identical proteins and their annotated locations for NP_112513.1

Status: VALIDATED

Source sequence(s)

AB005052, BC169096

UniProtKB/TrEMBL

B5DFK5, Q99PW9

Conserved Domains (5) summary

smart00307
Location:814 → 1012

ILWEQ; I/LWEQ domain

pfam07651
Location:28 → 300

ANTH; ANTH domain

pfam09728
Location:357 → 613

Taxilin; Myosin-like coiled-coil protein

pfam16515
Location:461 → 559

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

cl23720
Location:349 → 467

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

38251085..38279756 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271700.1 → XP_063127770.1 huntingtin-interacting protein 1-related protein isoform X2
XM_063271699.1 → XP_063127769.1 huntingtin-interacting protein 1-related protein isoform X1
XM_063271702.1 → XP_063127772.1 huntingtin-interacting protein 1-related protein isoform X4
XM_008769267.4 → XP_008767489.1 huntingtin-interacting protein 1-related protein isoform X6

UniProtKB/TrEMBL

Q99PW9

Conserved Domains (5) summary

smart00307
Location:821 → 1019

ILWEQ; I/LWEQ domain

pfam07651
Location:28 → 300

ANTH; ANTH domain

pfam09728
Location:357 → 613

Taxilin; Myosin-like coiled-coil protein

pfam16515
Location:461 → 559

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

cl23720
Location:349 → 467

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_063271701.1 → XP_063127771.1 huntingtin-interacting protein 1-related protein isoform X3
XM_008769266.4 → XP_008767488.1 huntingtin-interacting protein 1-related protein isoform X5

UniProtKB/TrEMBL

Q99PW9

Conserved Domains (5) summary

smart00307
Location:822 → 1020

ILWEQ; I/LWEQ domain

pfam07651
Location:28 → 300

ANTH; ANTH domain

pfam09728
Location:358 → 614

Taxilin; Myosin-like coiled-coil protein

pfam16515
Location:462 → 560

HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

cl23720
Location:350 → 468

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_063271703.1 → XP_063127773.1 huntingtin-interacting protein 1-related protein isoform X7