LBD18 LOB domain-containing protein 18 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: LBD18
Official Full Name: LOB domain-containing protein 18
Primary source: TAIR:AT2G45420
Locus tag: AT2G45420
See related: Araport:AT2G45420
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F4L23.7; LOB domain-containing protein 18
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Genomic context

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See LBD18 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 2

Sequence:: Chromosome: 2; NC_003071.7 (18718348..18720729)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LBD18 and IAA14 antagonistically interact with ARF7 via the invariant Lys and acidic residues of the OPCA motif in the PB1 domain.
Title: LBD18 and IAA14 antagonistically interact with ARF7 via the invariant Lys and acidic residues of the OPCA motif in the PB1 domain.
uses a dual mode of a positive feedback loop to regulate ARF expression and transcriptional activity
Title: LBD18 uses a dual mode of a positive feedback loop to regulate ARF expression and transcriptional activity in Arabidopsis.
acts downstream of ARF7 and ARF19 in formation of adventitious roots
Title: LBD16 and LBD18 acting downstream of ARF7 and ARF19 are involved in adventitious root formation in Arabidopsis.
conserved Leu or Val residues in the coiled-coil motifs of LBD16 and LBD18 are critical for their dimerization as well as the transcriptional regulation to display their biological functions.
Title: Coiled-coil motif in LBD16 and LBD18 transcription factors are critical for dimerization and biological function in arabidopsis.
Data show that the conserved Leu or valine residues in the coiled-coil motif are critical for the dimerization of LBD16 or LBD18 transcription factors.
Title: Dimerization in LBD16 and LBD18 Transcription Factors Is Critical for Lateral Root Formation.
Results suggest that Lateral Organ Boundaries Domain16 and 18 (LBD16 and LBD18) are important regulators of lateral root (LR) initiation and development downstream of AUXIN1 (AUX1) and LIKE-AUXIN3 (LAX3) auxin influx carriers.
Title: Lateral Organ Boundaries Domain16 and 18 Act Downstream of the AUXIN1 and LIKE-AUXIN3 Auxin Influx Carriers to Control Lateral Root Development in Arabidopsis.
This study revealed the molecular function of LBD18 as a specific DNA-binding transcription factor that activates EXP14 expression by directly binding to its promoter.
Title: LBD18 acts as a transcriptional activator that directly binds to the EXPANSIN14 promoter in promoting lateral root emergence of Arabidopsis.
GBF INTERACTING PROTEIN1 (GIP1) interacts with LBD18 in yeast and Arabidopsis protoplasts. Reverse-transcription-pcr analysis showed overlapping expression of GIP1 and LBD18 in roots, aerial parts, and rosette leaves of Arabidopsis.
Title: GIP1 may act as a coactivator that enhances transcriptional activity of LBD18 in Arabidopsis.
PUCHI co-acts with LBD16 and LBD18 to control lateral root primordium development and lateral root emergence.
Title: The AP2/EREBP gene PUCHI Co-Acts with LBD16/ASL18 and LBD18/ASL20 downstream of ARF7 and ARF19 to regulate lateral root development in Arabidopsis.
Results suggest that LBD18 up-regulates EXPA17 to enhance cell separation to promote lateral roots (LRs) emergence in Arabidopsis.
Title: EXPANSINA17 up-regulated by LBD18/ASL20 promotes lateral root formation during the auxin response.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_180105.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within callus formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral root formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylem development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: LOB domain-containing protein 18

NP_850436.1

LOB domain-containing protein 18 (LBD18); CONTAINS InterPro DOMAIN/s: Lateral organ boundaries, LOB (InterPro:IPR004883), Uncharacterised conserved protein UCP038127, LOB (InterPro:IPR017394); BEST Arabidopsis thaliana protein match is: Lateral organ boundaries (LOB) domain family protein (TAIR:AT4G00220.1); Has 12357 Blast hits to 5209 proteins in 472 species: Archae - 12; Bacteria - 2131; Metazoa - 4972; Fungi - 448; Plants - 3332; Viruses - 154; Other Eukaryotes - 1308 (source: NCBI BLink).