BEN1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BEN1
Official Full Name: NAD(P)-binding Rossmann-fold superfamily protein
Primary source: TAIR:AT2G45400
Locus tag: AT2G45400
See related: Araport:AT2G45400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BRI1-5 ENHANCED 1; F4L23.9
Summary: involved in the regulation of brassinosteroid metabolic pathway
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Genomic context

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See BEN1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 4

Sequence:: Chromosome: 2; NC_003071.7 (18703772..18706401, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Seryl-tRNA Synthetase:BEN1 complex is one of the first protein complexes of plant aminoacyl-tRNA synthetase discovered so far, and is a rare example of an aminoacyl-tRNA synthetase interacting with an enzyme involved in primary or secondary metabolism.
Title: Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase.
BEN1 and BEN2 are collectively required for polar PIN localization, for their dynamic repolarization, and consequently for auxin activity gradient formation and auxin-related developmental processes
Title: Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana.
Results identify BEN1 as the ARF GEF vesicle trafficking regulator mediating early endosomal traffic.
Title: Fluorescence imaging-based screen identifies ARF GEF component of early endosomal trafficking.
Analyses of brassinosteroid profiles demonstrated that BEN1 is indeed responsible for regulating the levels of several brassinosteroids, including typhasterol, castasterone and brassinolide.
Title: BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana.

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General gene information

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NM_001337127.1

Supported by ESTs:

NM_001337128.1

Supported by ESTs:

NM_001337129.1

Supported by ESTs:

NM_130102.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Process	Evidence Code	Pubs
involved_in brassinosteroid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brassinosteroid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flavonoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of brassinosteroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to absence of light	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: NAD(P)-binding Rossmann-fold superfamily protein

NP_182064.1

BEN1; FUNCTIONS IN: coenzyme binding, oxidoreductase activity, acting on CH-OH group of donors, binding, catalytic activity; INVOLVED IN: regulation of brassinosteroid biosynthetic process, brassinosteroid metabolic process, response to light intensity, flavonoid biosynthetic process; LOCATED IN: cytoplasm; EXPRESSED IN: 13 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: dihydroflavonol 4-reductase (TAIR:AT5G42800.1); Has 8852 Blast hits to 8839 proteins in 1531 species: Archae - 135; Bacteria - 3285; Metazoa - 357; Fungi - 858; Plants - 2633; Viruses - 7; Other Eukaryotes - 1577 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18703772..18706401 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130102.5 → NP_182064.1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_182064.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22133

UniProtKB/TrEMBL

A0A5S9X770

Conserved Domains (2) summary

PLN02650
Location:36 → 364

PLN02650; dihydroflavonol-4-reductase

cd08958
Location:40 → 341

FR_SDR_e; flavonoid reductase (FR), extended (e) SDRs
NM_001337127.1 → NP_001323894.1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AYD5, A0A5S9X770
NM_001337128.1 → NP_001323895.1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AYJ1, A0A5S9X770
NM_001337129.1 → NP_001323896.1 NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VQM9, A0A1P8AYJ2