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CRR4 Pentatricopeptide repeat (PPR) superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819143, updated on 18-Sep-2024

Summary

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Official Symbol
CRR4
Official Full Name
Pentatricopeptide repeat (PPR) superfamily protein
Primary source
TAIR:AT2G45350
Locus tag
AT2G45350
See related
Araport:AT2G45350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CHLORORESPIRATORY REDUCTION 4; F4L23.14
Summary
Encodes a member of a PCMP (plant combinatorial and modular protein) family (PCMP-E subfamily) with 11 pentatricopeptide (PPR) repeats. The protein is involved in RNA editing of the initiation codon of ndhD in the chloroplast.
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Genomic context

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See CRR4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
1
Sequence:
Chromosome: 2; NC_003071.7 (18694816..18696691, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene polyphosphatidylinositol phosphatase Neighboring gene RNA 2'-phosphotransferase, Tpt1 / KptA family Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ankyrin repeat/KH domain protein (DUF1442) Neighboring gene ncRNA Neighboring gene myeloid leukemia factor Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A pentatricopeptide repeat protein is a site recognition factor in chloroplast RNA editing. Okuda K, et al. J Biol Chem, 2006 Dec 8. PMID 17015439
  2. A pentatricopeptide repeat protein is essential for RNA editing in chloroplasts. Kotera E, et al. Nature, 2005 Jan 20. PMID 15662426
  3. Two interacting proteins are necessary for the editing of the NdhD-1 site in Arabidopsis plastids. Boussardon C, et al. Plant Cell, 2012 Sep. PMID 23001034, Free PMC Article
  4. Large-scale characterization of integral proteins from Arabidopsis vacuolar membrane by two-dimensional liquid chromatography. Szponarski W, et al. Proteomics, 2004 Feb. PMID 14760709
  5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DYW1, by interaction with CRR4, provides in trans an essential function required for editing of the ndhD-1 site.
    Title: Two interacting proteins are necessary for the editing of the NdhD-1 site in Arabidopsis plastids.
  2. the pentatricopeptide repeat protein CRR4 is a sequence-specific RNA-binding protein that acts as a site recognition factor in plastid RNA editing
    Title: A pentatricopeptide repeat protein is a site recognition factor in chloroplast RNA editing.
  3. crr4 is among genes responsible for the specific RNA editing event in the chloroplast [CRR4]
    Title: A pentatricopeptide repeat protein is essential for RNA editing in chloroplasts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_130098.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chloroplast RNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
Pentatricopeptide repeat (PPR) superfamily protein
NP_182060.2
  • CHLORORESPIRATORY REDUCTION 4 (CRR4); INVOLVED IN: mRNA modification; LOCATED IN: chloroplast, vacuole; CONTAINS InterPro DOMAIN/s: Pentatricopeptide repeat (InterPro:IPR002885); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT4G02750.1); Has 36388 Blast hits to 13274 proteins in 208 species: Archae - 0; Bacteria - 3; Metazoa - 67; Fungi - 16; Plants - 35908; Viruses - 0; Other Eukaryotes - 394 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    18694816..18696691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130098.3 → NP_182060.2  Pentatricopeptide repeat (PPR) superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_182060.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22137
    UniProtKB/TrEMBL
    A0A178W0U9
    Conserved Domains (4) summary
    sd00004
    Location:254 → 281
    PPR; PPR repeat [structural motif]
    pfam01535
    Location:253 → 283
    PPR; PPR repeat
    pfam12854
    Location:280 → 310
    PPR_1; PPR repeat
    pfam13041
    Location:250 → 295
    PPR_2; PPR repeat family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22137.2

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