ATCS Citrate synthase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATCS
Official Full Name: Citrate synthase family protein
Primary source: TAIR:AT2G44350
Locus tag: AT2G44350
See related: Araport:AT2G44350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CITRATE SYNTHASE 4; CSY4; F4I1.16
Summary: encodes a mitochrondrion targeted citrate synthase, the first enzyme of the tricarboxylic acid cycle, catalyzing the condensation of acetyl-CoA and oxaloacetate, finally yielding citrate and CoA.
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Genomic context

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See ATCS in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 21

Sequence:: Chromosome: 2; NC_003071.7 (18316278..18320789)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Redox regulation of Arabidopsis mitochondrial citrate synthase
Title: Redox regulation of Arabidopsis mitochondrial citrate synthase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001337082.1

Supported by ESTs:

NM_001337083.1

Supported by ESTs:

NM_129998.3

Supported by ESTs:

NM_180084.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	HDA more info	PubMed
enables citrate (Si)-synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in citrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tricarboxylic acid cycle	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
NOT located_in Golgi apparatus	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in plant-type cell wall	HDA more info	PubMed

General protein information

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Preferred Names: Citrate synthase family protein

NP_566016.1

ATCS; FUNCTIONS IN: citrate (SI)-synthase activity, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion, tricarboxylic acid cycle; LOCATED IN: mitochondrion, cell wall, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Citrate synthase-like, large alpha subdomain (InterPro:IPR016142), Citrate synthase, eukaryotic (InterPro:IPR010109), Citrate synthase active site (InterPro:IPR019810), Citrate synthase-like (InterPro:IPR002020), Citrate synthase-like, core (InterPro:IPR016141); BEST Arabidopsis thaliana protein match is: citrate synthase 5 (TAIR:AT3G60100.1); Has 10534 Blast hits to 10528 proteins in 2768 species: Archae - 158; Bacteria - 6911; Metazoa - 258; Fungi - 320; Plants - 178; Viruses - 0; Other Eukaryotes - 2709 (source: NCBI BLink).

NP_850415.1

ATCS; FUNCTIONS IN: citrate (SI)-synthase activity, zinc ion binding, ATP binding; INVOLVED IN: response to cadmium ion, tricarboxylic acid cycle; LOCATED IN: mitochondrion, cell wall, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Citrate synthase-like, large alpha subdomain (InterPro:IPR016142), Citrate synthase, eukaryotic (InterPro:IPR010109), Citrate synthase active site (InterPro:IPR019810), Citrate synthase-like, core (InterPro:IPR016141), Citrate synthase-like (InterPro:IPR002020); BEST Arabidopsis thaliana protein match is: citrate synthase 5 (TAIR:AT3G60100.1); Has 10608 Blast hits to 10602 proteins in 2793 species: Archae - 158; Bacteria - 6984; Metazoa - 258; Fungi - 321; Plants - 178; Viruses - 0; Other Eukaryotes - 2709 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18316278..18320789

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180084.2 → NP_850415.1 Citrate synthase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850415.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O64869, P20115, Q8LE36, Q94EY6

UniProtKB/TrEMBL

A0A7G2EHB4

Conserved Domains (2) summary

cd06105
Location:41 → 467

ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...

PLN02456
Location:9 → 474

PLN02456; citrate synthase
NM_129998.3 → NP_566016.1 Citrate synthase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566016.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VUU3, A0A5S9X6X1, A0A7G2EHB4

Conserved Domains (1) summary

cd06105
Location:40 → 466

ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
NM_001337082.1 → NP_001324514.1 Citrate synthase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O64869, P20115, Q8LE36, Q94EY6

UniProtKB/TrEMBL

A0A7G2EHB4
NM_001337083.1 → NP_001324515.1 Citrate synthase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VUU3, A0A5S9X6X1, A0A7G2EHB4

Conserved Domains (1) summary

cd06105
Location:40 → 466

ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...