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COS1 6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819010, updated on 18-Sep-2024

Summary

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Official Symbol
COS1
Official Full Name
6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase
Primary source
TAIR:AT2G44050
Locus tag
AT2G44050
See related
Araport:AT2G44050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
COI1 SUPPRESSOR1; coronatine insensitive1 suppressor; F6E13.18
Summary
6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase [Arabidopsis thaliana]. Acts in the jasmonic acid signaling pathway.
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Genomic context

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See COS1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Sequence:
Chromosome: 2; NC_003071.7 (18224213..18226233)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Dihydrodipicolinate reductase, bacterial/plant Neighboring gene Late embryogenesis abundant protein, group 2 Neighboring gene Ribosomal protein L2 family Neighboring gene NagB/RpiA/CoA transferase-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. COS1: an Arabidopsis coronatine insensitive1 suppressor essential for regulation of jasmonate-mediated plant defense and senescence. Xiao S, et al. Plant Cell, 2004 May. PMID 15075400, Free PMC Article
  2. Plant riboflavin biosynthesis. Cloning, chloroplast localization, expression, purification, and partial characterization of spinach lumazine synthase. Jordan DB, et al. J Biol Chem, 1999 Jul 30. PMID 10419541
  3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
  4. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
  5. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_129967.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 6,7-dimethyl-8-ribityllumazine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 6,7-dimethyl-8-ribityllumazine synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within jasmonic acid mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within riboflavin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
part_of riboflavin synthase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase
NP_181933.1
  • COI1 SUPPRESSOR1 (COS1); FUNCTIONS IN: 6,7-dimethyl-8-ribityllumazine synthase activity; INVOLVED IN: riboflavin biosynthetic process, jasmonic acid mediated signaling pathway; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 6,7-dimethyl-8-ribityllumazine synthase (InterPro:IPR002180), 6,7-dimethyl-8-ribityllumazine synthase, chloroplast (InterPro:IPR017420); Has 7351 Blast hits to 7351 proteins in 2325 species: Archae - 190; Bacteria - 4938; Metazoa - 2; Fungi - 209; Plants - 81; Viruses - 0; Other Eukaryotes - 1931 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    18224213..18226233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129967.4 → NP_181933.1  6,7-dimethyl-8-ribityllumazine synthase / DMRL synthase / lumazine synthase / riboflavin synthase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181933.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O80575
    UniProtKB/TrEMBL
    A0A178VP65, A0A5S9X6U7, A0A7G2EHZ0
    Conserved Domains (1) summary
    PLN02404
    Location:78 → 218
    PLN02404; 6,7-dimethyl-8-ribityllumazine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O80575.1

Gene LinkOut

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