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ETFQO electron-transfer flavoprotein:ubiquinone oxidoreductase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818941, updated on 18-Sep-2024

Summary

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Official Symbol
ETFQO
Official Full Name
electron-transfer flavoprotein:ubiquinone oxidoreductase
Primary source
TAIR:AT2G43400
Locus tag
AT2G43400
See related
Araport:AT2G43400
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
electron-transfer flavoprotein:ubiquinone oxidoreductase; T1O24.14
Summary
Encodes a unique electron-transfer flavoprotein:ubiquinone oxidoreductase that is localized to the mitochondrion. Mutants are more sensitive to sugar starvation when plants are kept in the dark for long periods.
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Genomic context

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See ETFQO in Genome Data Viewer
Location:
chromosome: 2
Exon count:
18
Sequence:
Chromosome: 2; NC_003071.7 (18021109..18025292)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene RNA binding protein Neighboring gene 3-beta hydroxysteroid dehydrogenase/isomerase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation. Ishizaki K, et al. Plant Cell, 2005 Sep. PMID 16055629, Free PMC Article
  2. The Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination. da Fonseca-Pereira P, et al. Plant J, 2022 Jan. PMID 34741366
  3. Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. Araújo WL, et al. Plant Cell, 2010 May. PMID 20501910, Free PMC Article
  4. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
  5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination.
    Title: The Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination.
  2. Data demonstrate the involvement of ETFQO in the catabolism of leucine in higher plants and imply a novel role for this protein in the chlorophyll degradation pathway activated during dark-induced senescence and sugar starvation.
    Title: The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001337026.1
NM_129901.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables electron-transferring-flavoprotein dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-leucine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within alternative respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to absence of light IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
electron-transfer flavoprotein:ubiquinone oxidoreductase
NP_181868.1
  • electron-transfer flavoprotein:ubiquinone oxidoreductase (ETFQO); FUNCTIONS IN: electron carrier activity, catalytic activity, electron-transferring-flavoprotein dehydrogenase activity; INVOLVED IN: response to absence of light, leucine catabolic process; LOCATED IN: mitochondrial envelope, mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Electron transfer flavoprotein-ubiquinone oxidoreductase (InterPro:IPR007859); Has 5881 Blast hits to 5877 proteins in 1100 species: Archae - 188; Bacteria - 2470; Metazoa - 147; Fungi - 158; Plants - 31; Viruses - 0; Other Eukaryotes - 2887 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    18021109..18025292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129901.4 → NP_181868.1  electron-transfer flavoprotein:ubiquinone oxidoreductase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22854
    UniProtKB/TrEMBL
    A0A178VYB8, A0A5S9X6N7, A0A654F6R0
    Conserved Domains (2) summary
    COG0644
    Location:97 → 546
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    pfam05187
    Location:529 → 631
    ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S

  2. NM_001337026.1 → NP_001324650.1  electron-transfer flavoprotein:ubiquinone oxidoreductase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B0T2, A0A654F6R0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22854.1

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