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GPX3 glutathione peroxidase 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818936, updated on 18-Sep-2024

Summary

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Official Symbol
GPX3
Official Full Name
glutathione peroxidase 3
Primary source
TAIR:AT2G43350
Locus tag
AT2G43350
See related
Araport:AT2G43350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATGPX3; glutathione peroxidase 3; T1O24.9
Summary
Glutathione peroxidase. Functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses. Interacts with ABI2 and ABI1.
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Genomic context

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See GPX3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (18008482..18010614, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene hypothetical protein (DUF1685) Neighboring gene ncRNA Neighboring gene Radical SAM superfamily protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Arabidopsis glutathione peroxidase functions as both a redox transducer and a scavenger in abscisic acid and drought stress responses. Miao Y, et al. Plant Cell, 2006 Oct. PMID 16998070, Free PMC Article
  2. Glutathione peroxidase-like enzymes cover five distinct cell compartments and membrane surfaces in Arabidopsis thaliana. Attacha S, et al. Plant Cell Environ, 2017 Aug. PMID 28102911
  3. Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways. Rodriguez Milla MA, et al. Plant J, 2003 Dec. PMID 14617062
  4. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article
  5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001202813.1
NM_129896.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome HDA PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in trans-Golgi network HDA PubMed 

General protein information

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Preferred Names
glutathione peroxidase 3
NP_001189742.1
  • glutathione peroxidase 3 (GPX3); FUNCTIONS IN: glutathione peroxidase activity; INVOLVED IN: response to hydrogen peroxide, abscisic acid mediated signaling pathway, cellular response to water deprivation; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336), Glutathione peroxidase (InterPro:IPR000889); BEST Arabidopsis thaliana protein match is: glutathione peroxidase 1 (TAIR:AT2G25080.1).
NP_181863.1
  • glutathione peroxidase 3 (GPX3); FUNCTIONS IN: glutathione peroxidase activity; INVOLVED IN: response to hydrogen peroxide, abscisic acid mediated signaling pathway, cellular response to water deprivation; LOCATED IN: mitochondrion; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336), Glutathione peroxidase (InterPro:IPR000889); BEST Arabidopsis thaliana protein match is: glutathione peroxidase 1 (TAIR:AT2G25080.1); Has 7324 Blast hits to 7323 proteins in 1740 species: Archae - 2; Bacteria - 3505; Metazoa - 790; Fungi - 210; Plants - 383; Viruses - 8; Other Eukaryotes - 2426 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    18008482..18010614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202813.1 → NP_001189742.1  glutathione peroxidase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189742.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22850
    UniProtKB/TrEMBL
    A0A5S9X754, A0A654F1H7
    Conserved Domains (1) summary
    cl00388
    Location:42 → 206
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. NM_129896.4 → NP_181863.1  glutathione peroxidase 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181863.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22850
    UniProtKB/TrEMBL
    A0A5S9X754, A0A654F1H7
    Conserved Domains (1) summary
    cl00388
    Location:42 → 206
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22850.1

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