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HOS1 ubiquitin-protein ligase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818568, updated on 18-Sep-2024

Summary

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Official Symbol
HOS1
Official Full Name
ubiquitin-protein ligase
Primary source
TAIR:AT2G39810
Locus tag
AT2G39810
See related
Araport:AT2G39810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
EARLY IN SHORT DAYS 6; ESD6; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1; T5I7.11; T5I7_11
Summary
A novel protein with a RING finger motif near the amino terminus. Negative regulator of cold responses. Functions as an E3 ligase required for the ubiquitination of ICE1. HOS1 physically interacts with ICE1 and mediates the ubiquitination of ICE1 both in vitro and in vivo. Overexpression represses the expression of CBFs and their downstream genes and confers increased sensitivity to freezing stress.
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Genomic context

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See HOS1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Sequence:
Chromosome: 2; NC_003071.7 (16612777..16618122)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Mitochondrial glycoprotein family protein Neighboring gene delta1-pyrroline-5-carboxylate synthase 1 Neighboring gene Integral membrane Yip1 family protein Neighboring gene Translation initiation factor IF6 Neighboring gene DA1-related protein 2 Neighboring gene type one serine/threonine protein phosphatase 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase. Margalha L, et al. Plant J, 2023 Aug. PMID 37077033
  2. The Arabidopsis HOS1 gene negatively regulates cold signal transduction and encodes a RING finger protein that displays cold-regulated nucleo--cytoplasmic partitioning. Lee H, et al. Genes Dev, 2001 Apr 1. PMID 11297514, Free PMC Article
  3. Molecular genetic analysis of cold-regulated gene transcription. Viswanathan C, et al. Philos Trans R Soc Lond B Biol Sci, 2002 Jul 29. PMID 12171651, Free PMC Article
  4. HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 is required for circadian periodicity through the promotion of nucleo-cytoplasmic mRNA export in Arabidopsis. MacGregor DR, et al. Plant Cell, 2013 Nov. PMID 24254125, Free PMC Article
  5. HOS1 acts as a key modulator of hypocotyl photomorphogenesis. Kim JH, et al. Plant Signal Behav, 2017 May 4. PMID 28426369, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The HOS1-PIF4/5 module controls callus formation in Arabidopsis leaf explants.
    Title: The HOS1-PIF4/5 module controls callus formation in Arabidopsis leaf explants.
  2. HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase.
    Title: HOS1 promotes plant tolerance to low-energy stress via the SnRK1 protein kinase.
  3. Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis.
    Title: Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis.
  4. Nup96 and HOS1 Are Mutually Stabilized and Gate CONSTANS Protein Level, Conferring Long-Day Photoperiodic Flowering Regulation in Arabidopsis.
    Title: Nup96 and HOS1 Are Mutually Stabilized and Gate CONSTANS Protein Level, Conferring Long-Day Photoperiodic Flowering Regulation in Arabidopsis.
  5. While HOS1 is known to act as an E3 ubiquitin ligase or a chromatin remodeling factor, data illustrate a novel role of HOS1: it acts as a component of phyB-mediated light signaling in hypocotyl photomorphogenesis.
    Title: HOS1 acts as a key modulator of hypocotyl photomorphogenesis.
  6. HOS1 is intimately linked with hypocotyl growth, in which HOS1 inhibits the transcriptional activation activity of PIF4
    Title: HOS1 Facilitates the Phytochrome B-Mediated Inhibition of PIF4 Function during Hypocotyl Growth in Arabidopsis.
  7. Red light-mediated degradation of CO protein by HOS1 ligase regulates photoperiodic flowering in Arabidopsis.HOS1 and PHYB regulate flowering time additively.
    Title: Red Light-Mediated Degradation of CONSTANS by the E3 Ubiquitin Ligase HOS1 Regulates Photoperiodic Flowering in Arabidopsis.
  8. HOS1 regulates miR168a/b and AGO1 levels in Arabidopsis by maintaining proper transcription of MIR168b.
    Title: HOS1 regulates Argonaute1 by promoting transcription of the microRNA gene MIR168b in Arabidopsis.
  9. HOS1 regulates FLC transcription via chromatin remodeling.
    Title: HOS1-mediated activation of FLC via chromatin remodeling under cold stress.
  10. HOS1 is required for circadian periodicity through the promotion of nucleo-cytoplasmic mRNA export.
    Title: HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 is required for circadian periodicity through the promotion of nucleo-cytoplasmic mRNA export in Arabidopsis.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001336798.1
NM_129540.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vegetative to reproductive phase transition of meristem IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
ubiquitin-protein ligase
NP_181511.3
  • HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: response to cold, negative regulation of transcription, protein ubiquitination; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; Has 239 Blast hits to 237 proteins in 68 species: Archae - 0; Bacteria - 0; Metazoa - 131; Fungi - 0; Plants - 80; Viruses - 5; Other Eukaryotes - 23 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16612777..16618122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129540.5 → NP_181511.3  ubiquitin-protein ligase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181511.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22289, Q84JU6
    UniProtKB/TrEMBL
    A0A178W236, A0A5S9X5M0, A0A654F0D1
    Conserved Domains (2) summary
    pfam13934
    Location:323 → 596
    ELYS; Nuclear pore complex assembly
    cl17238
    Location:66 → 93
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_001336798.1 → NP_001324757.1  ubiquitin-protein ligase [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B159, A0A654F0D1, A0A7G2EFT6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84JU6.1

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