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RNS2 ribonuclease 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818563, updated on 18-Sep-2024

Summary

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Official Symbol
RNS2
Official Full Name
ribonuclease 2
Primary source
TAIR:AT2G39780
Locus tag
AT2G39780
See related
Araport:AT2G39780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ribonuclease 2; T5I7.8; T5I7_8
Summary
Encodes the main endoribonuclease activity in plant cells and localizes to the endoplasmic reticulum (ER), ER-derived structures, and vacuoles. It is essential for normal ribosomal RNA recycling.
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Genomic context

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See RNS2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (16591117..16593775)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Glucose-1-phosphate adenylyltransferase family protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial glycoprotein family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNS2 is required for the biogenesis of a wounding responsive 16 nts tsRNA in Arabidopsis thaliana. Chen Y, et al. Plant Mol Biol, 2024 Jan 24. PMID 38265739
  2. Cell growth and homeostasis are disrupted in arabidopsis rns2-2 mutants missing the main vacuolar RNase activity. Morriss SC, et al. Ann Bot, 2017 Nov 28. PMID 28961890, Free PMC Article
  3. Localization of RNS2 ribonuclease to the vacuole is required for its role in cellular homeostasis. Floyd BE, et al. Planta, 2017 Apr. PMID 28025674
  4. RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay in plants. Hillwig MS, et al. Proc Natl Acad Sci U S A, 2011 Jan 18. PMID 21199950, Free PMC Article
  5. Regulation of S-like ribonuclease levels in Arabidopsis. Antisense inhibition of RNS1 or RNS2 elevates anthocyanin accumulation. Bariola PA, et al. Plant Physiol, 1999 Jan. PMID 9880376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNS2 is required for the biogenesis of a wounding responsive 16 nts tsRNA in Arabidopsis thaliana.
    Title: RNS2 is required for the biogenesis of a wounding responsive 16 nts tsRNA in Arabidopsis thaliana.
  2. Lack of rRNA recycling in rns2-2 cells triggers a change in carbon flux, which is redirected through the pentose phosphate pathway to produce ribose-5-phosphate for de novo nucleoside synthesis. rRNA or ribosome turnover is thus essential for cellular homeostasis, probably through maintenance of nucleoside levels as part of the salvage pathway.
    Title: Cell growth and homeostasis are disrupted in arabidopsis rns2-2 mutants missing the main vacuolar RNase activity.
  3. intracellular retention and localization within the vacuole are critical for its cellular function
    Title: Localization of RNS2 ribonuclease to the vacuole is required for its role in cellular homeostasis.
  4. RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay.
    Title: RNS2, a conserved member of the RNase T2 family, is necessary for ribosomal RNA decay in plants.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001125006.1
NM_129536.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonuclease T2 activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ER body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plant-type vacuole HDA PubMed 
located_in vacuole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribonuclease 2
NP_001118478.1
  • ribonuclease 2 (RNS2); FUNCTIONS IN: ribonuclease T2 activity, endoribonuclease activity, RNA binding; INVOLVED IN: aging; LOCATED IN: intracellular; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ribonuclease T2 (InterPro:IPR001568), Ribonuclease T2, active site (InterPro:IPR018188); BEST Arabidopsis thaliana protein match is: Ribonuclease T2 family protein (TAIR:AT1G14220.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_030524.1
  • ribonuclease 2 (RNS2); FUNCTIONS IN: ribonuclease T2 activity, endoribonuclease activity, RNA binding; INVOLVED IN: aging; LOCATED IN: intracellular, vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ribonuclease T2 (InterPro:IPR001568), Ribonuclease T2, active site (InterPro:IPR018188); BEST Arabidopsis thaliana protein match is: Ribonuclease T2 family protein (TAIR:AT1G14220.1); Has 2318 Blast hits to 2317 proteins in 471 species: Archae - 0; Bacteria - 380; Metazoa - 295; Fungi - 231; Plants - 1299; Viruses - 5; Other Eukaryotes - 108 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16591117..16593775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129536.5 → NP_030524.1  ribonuclease 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_030524.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42814, Q42136
    UniProtKB/TrEMBL
    A0A5S9X5I7, A0A7G2EHU0, Q1ECE2
    Conserved Domains (1) summary
    pfam00445
    Location:32 → 219
    Ribonuclease_T2; Ribonuclease T2 family

  2. NM_001125006.1 → NP_001118478.1  ribonuclease 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118478.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654F1N6, A0A7G2EHU0, F4IW05
    Conserved Domains (1) summary
    pfam00445
    Location:32 → 187
    Ribonuclease_T2; Ribonuclease T2 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42814.1

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