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HESO1 Nucleotidyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818559, updated on 18-Sep-2024

Summary

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Official Symbol
HESO1
Official Full Name
Nucleotidyltransferase family protein
Primary source
TAIR:AT2G39740
Locus tag
AT2G39740
See related
Araport:AT2G39740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
HEN1 suppressor 1; T5I7.4; T5I7_4
Summary
Encodes HESO1 (HEN1 suppressor 1), a terminal nucleotidyl transferase that uridylates miRNAs and siRNAs at 3' end. HESO1-mediated 3' uridylation destabilizes small RNAs in hen1.
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Genomic context

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See HESO1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (16575752..16579120)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RING-H2 finger C2A Neighboring gene LYR family of Fe/S cluster biogenesis protein Neighboring gene rubisco activase Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene BTB/POZ/MATH-domains containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HEN1 SUPPRESSOR1 stabilizes polymerase IV RNAs via uridylation in Arabidopsis. Ren Y, et al. Plant Physiol, 2023 Aug 31. PMID 37217838
  2. The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation. Zhao Y, et al. Curr Biol, 2012 Apr 24. PMID 22464194, Free PMC Article
  3. Uridylation of miRNAs by hen1 suppressor1 in Arabidopsis. Ren G, et al. Curr Biol, 2012 Apr 24. PMID 22464191, Free PMC Article
  4. Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis. Tu B, et al. PLoS Genet, 2015 Apr. PMID 25928405, Free PMC Article
  5. Synergistic and independent actions of multiple terminal nucleotidyl transferases in the 3' tailing of small RNAs in Arabidopsis. Wang X, et al. PLoS Genet, 2015 Apr. PMID 25928341, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HEN1 SUPPRESSOR1 stabilizes polymerase IV RNAs via uridylation in Arabidopsis.
    Title: HEN1 SUPPRESSOR1 stabilizes polymerase IV RNAs via uridylation in Arabidopsis.
  2. URT1 and HESO1 prefer substrates with different 3' end nucleotides in vitro and act cooperatively to tail different forms of the same miRNAs in vivo. Moreover, both HESO1 and URT1 exhibit nucleotidyl transferase activity on AGO1-bound miRNAs
    Title: Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis.
  3. our data not only reveal a synergistic action of HESO1 and URT1 in the 3' uridylation of miRNAs, but also independent activities of multiple terminal nucleotidyl transferases in the 3' tailing of small RNAs
    Title: Synergistic and independent actions of multiple terminal nucleotidyl transferases in the 3' tailing of small RNAs in Arabidopsis.
  4. HESO1 encodes a terminal nucleotidyl transferase that prefers to add untemplated uridine to the 3' end of RNA, which is completely abolished by 2'-O-methylation.[HESO1]
    Title: Uridylation of miRNAs by hen1 suppressor1 in Arabidopsis.
  5. HESO1 gene is responsible for small RNA uridylation and exhibits terminal nucleotidyl transferase activity, prefers uridine as the substrate nucleotide, and is completely inhibited by 2'-O-methylation.[HESO1]
    Title: The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001336793.1
NM_001336794.1
NM_129532.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables RNA uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotidyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA 3' uridylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within RNA 3' uridylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Nucleotidyltransferase family protein
NP_001318386.1
  • Nucleotidyltransferase family protein; BEST Arabidopsis thaliana protein match is: Nucleotidyltransferase family protein (TAIR:AT3G45750.1); Has 1708 Blast hits to 1608 proteins in 227 species: Archae - 0; Bacteria - 13; Metazoa - 799; Fungi - 328; Plants - 255; Viruses - 0; Other Eukaryotes - 313 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16575752..16579120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336793.1 → NP_001318386.1  Nucleotidyltransferase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22284, Q0WSQ3, Q5XET5
    UniProtKB/TrEMBL
    A0A178VNX4, A0A7G2EGU0
    Conserved Domains (1) summary
    COG5260
    Location:11 → 436
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. NM_001336794.1 → NP_001324414.1  Nucleotidyltransferase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22284, Q0WSQ3, Q5XET5
    UniProtKB/TrEMBL
    A0A178VNX4, A0A7G2EGU0
    Conserved Domains (1) summary
    COG5260
    Location:11 → 436
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  3. NM_129532.4 → NP_181504.2  Nucleotidyltransferase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181504.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22284, Q0WSQ3, Q5XET5
    UniProtKB/TrEMBL
    A0A178VNX4, A0A7G2EGU0
    Conserved Domains (1) summary
    COG5260
    Location:11 → 436
    TRF4; DNA polymerase sigma [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XET5.1

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