MTP11 Cation efflux family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MTP11
Official Full Name: Cation efflux family protein
Primary source: TAIR:AT2G39450
Locus tag: AT2G39450
See related: Araport:AT2G39450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMTP11; F12L6.11; F12L6_11
Summary: Encodes a Golgi-localized manganese transporter that is involved in Mn tolerance. When expressed into yeast cells, this gene confer Mn<sup>2+</sup> and Cu<sup>2+</sup> tolerance.
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Genomic context

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See MTP11 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 6

Sequence:: Chromosome: 2; NC_003071.7 (16471560..16474060, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of MTP11 in manganese transport and tolerance in A. thaliana and in transgenic S. cerevisiae is reported. [AtMTP11]
Title: A role for the AtMTP11 gene of Arabidopsis in manganese transport and tolerance.
Expression of the Arabidopsis and poplar MTP11 cation diffusion facilitators in a manganese-hypersensitive yeast mutant restores manganese tolerance to wild-type levels.[MTP11]
Title: A secretory pathway-localized cation diffusion facilitator confers plant manganese tolerance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_129503.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables manganese ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables manganese:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular manganese ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to copper ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to manganese ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to manganese ion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to manganese ion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Cation efflux family protein

NP_181477.1

MTP11; CONTAINS InterPro DOMAIN/s: Cation efflux protein (InterPro:IPR002524); BEST Arabidopsis thaliana protein match is: Cation efflux family protein (TAIR:AT1G79520.1); Has 5154 Blast hits to 5150 proteins in 1777 species: Archae - 162; Bacteria - 4222; Metazoa - 44; Fungi - 292; Plants - 207; Viruses - 0; Other Eukaryotes - 227 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

16471560..16474060 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129503.4 → NP_181477.1 Cation efflux family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181477.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DI01, O80632

UniProtKB/TrEMBL

A0A178VPD8, A0A5S9X5H8

Conserved Domains (1) summary

cl30791
Location:91 → 358

FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]