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FAC1 AMP deaminase, putative / myoadenylate deaminase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818408, updated on 18-Sep-2024

Summary

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Official Symbol
FAC1
Official Full Name
AMP deaminase, putative / myoadenylate deaminase
Primary source
TAIR:AT2G38280
Locus tag
AT2G38280
See related
Araport:AT2G38280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ADENOSINE 5'-MONOPHOSPHATE DEAMINASE; ATAMPD; EMBRYONIC FACTOR1; F16M14.21; F16M14_21
Summary
Encodes a protein with in vitro AMP deaminase activity that is involved in embryogenesis. Homozygous mutant embryos fail to develop past the zygote stage.
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Genomic context

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See FAC1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
20
Sequence:
Chromosome: 2; NC_003071.7 (16033292..16038972, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene CAX-interacting protein 2 Neighboring gene ammonium transporter 2 Neighboring gene myb-like HTH transcriptional regulator family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray crystallographic analysis of adenosine 5'-monophosphate deaminase (AMPD) from Arabidopsis thaliana in complex with coformycin 5'-phosphate. Han BW, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2005 Aug 1. PMID 16511144, Free PMC Article
  2. EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis. Xu J, et al. Plant J, 2005 Jun. PMID 15918887
  3. Membrane association, mechanism of action, and structure of Arabidopsis embryonic factor 1 (FAC1). Han BW, et al. J Biol Chem, 2006 May 26. PMID 16543243
  4. Multiple lines of evidence localize signaling, morphology, and lipid biosynthesis machinery to the mitochondrial outer membrane of Arabidopsis. Duncan O, et al. Plant Physiol, 2011 Nov. PMID 21896887, Free PMC Article
  5. Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin. Lu Q, et al. Plant J, 2010 Jan. PMID 19843313

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the association between Arabidopsis FAC1 globular catalytic domain and intracellular membranes, with N-terminal transmembrane and disordered linker regions serving as the anchor and attachment to the globular catalytic domain
    Title: Membrane association, mechanism of action, and structure of Arabidopsis embryonic factor 1 (FAC1).
  2. preliminary X-ray crystallographic structure of adenosine 5'-monophosphate deaminase
    Title: Crystallization and preliminary X-ray crystallographic analysis of adenosine 5'-monophosphate deaminase (AMPD) from Arabidopsis thaliana in complex with coformycin 5'-phosphate.
  3. FAC1 is involved in early embryo development, most likely in providing sufficient ATP for embryo development to proceed beyond the zygote stage. [FAC1] [EMBRYONIC FACTOR 1]
    Title: EMBRYONIC FACTOR 1 encodes an AMP deaminase and is essential for the zygote to embryo transition in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_129384.3
NM_179963.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables AMP deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP deaminase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in IMP salvage IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AMP deaminase, putative / myoadenylate deaminase
NP_565886.1
  • EMBRYONIC FACTOR1 (FAC1); FUNCTIONS IN: AMP deaminase activity; INVOLVED IN: purine ribonucleoside monophosphate biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: cytosol, nucleus, microsome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Adenosine/AMP deaminase (InterPro:IPR001365), Adenosine/AMP deaminase active site (InterPro:IPR006650), AMP deaminase (InterPro:IPR006329); Has 1191 Blast hits to 1128 proteins in 362 species: Archae - 0; Bacteria - 226; Metazoa - 390; Fungi - 271; Plants - 78; Viruses - 0; Other Eukaryotes - 226 (source: NCBI BLink).
NP_850294.1
  • EMBRYONIC FACTOR1 (FAC1); FUNCTIONS IN: AMP deaminase activity; INVOLVED IN: purine ribonucleoside monophosphate biosynthetic process, embryo development ending in seed dormancy; LOCATED IN: cytosol, nucleus, microsome; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Adenosine/AMP deaminase (InterPro:IPR001365), Adenosine/AMP deaminase active site (InterPro:IPR006650), AMP deaminase (InterPro:IPR006329); Has 1191 Blast hits to 1128 proteins in 362 species: Archae - 0; Bacteria - 226; Metazoa - 390; Fungi - 271; Plants - 78; Viruses - 0; Other Eukaryotes - 226 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16033292..16038972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129384.3 → NP_565886.1  AMP deaminase, putative / myoadenylate deaminase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565886.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFX9, O80452, Q56XX1, Q93ZR9
    UniProtKB/TrEMBL
    A0A178VY66, A0A5S9X521
    Conserved Domains (1) summary
    PLN02768
    Location:1 → 839
    PLN02768; AMP deaminase

  2. NM_179963.3 → NP_850294.1  AMP deaminase, putative / myoadenylate deaminase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850294.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFX9, O80452, Q56XX1, Q93ZR9
    UniProtKB/TrEMBL
    A0A178VY66, A0A5S9X521
    Conserved Domains (1) summary
    PLN02768
    Location:1 → 839
    PLN02768; AMP deaminase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O80452.2

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