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ALS3 aluminum sensitive 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818310, updated on 18-Sep-2024

Summary

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Official Symbol
ALS3
Official Full Name
aluminum sensitive 3
Primary source
TAIR:AT2G37330
Locus tag
AT2G37330
See related
Araport:AT2G37330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ALUMINUM SENSITIVE 3; F3G5.12; F3G5_12
Summary
Encodes an ABC transporter-like protein, without an ATPase domain, required for aluminum (Al) resistance/tolerance and may function to redistribute accumulated Al away from sensitive tissues in order to protect the growing root from the toxic effects of Al.
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Genomic context

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See ALS3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (15669131..15670187)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene arginine/serine-rich zinc knuckle-containing protein 33 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ABC-2 type transporter family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression genome-wide association study identifies that phosphatidylinositol-derived signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots of Arabidopsis thaliana. Sadhukhan A, et al. Plant Sci, 2021 Jan. PMID 33288018
  2. An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots. Dong J, et al. Mol Plant, 2017 Feb 13. PMID 27847325
  3. Al Inhibits Both Shoot Development and Root Growth in als3, an Al-Sensitive Arabidopsis Mutant. Larsen PB, et al. Plant Physiol, 1997 Aug. PMID 12223767, Free PMC Article
  4. An ABC transporter complex encoded by Aluminum Sensitive 3 and NAP3 is required for phosphate deficiency responses in Arabidopsis. Belal R, et al. Biochem Biophys Res Commun, 2015 Jul 17-24. PMID 25983320
  5. Calmodulin-like protein CML24 interacts with CAMTA2 and WRKY46 to regulate ALMT1-dependent Al resistance in Arabidopsis thaliana. Zhu X, et al. New Phytol, 2022 Mar. PMID 34665465

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression genome-wide association study identifies that phosphatidylinositol-derived signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots of Arabidopsis thaliana.
    Title: Expression genome-wide association study identifies that phosphatidylinositol-derived signalling regulates ALUMINIUM SENSITIVE3 expression under aluminium stress in the shoots of Arabidopsis thaliana.
  2. evidence showing that ALS3 cooperates with LPR1/2 to regulate Pi deficiency-induced remodeling of root architecture by modulating Fe homeostasis in roots
    Title: An Arabidopsis ABC Transporter Mediates Phosphate Deficiency-Induced Remodeling of Root Architecture by Modulating Iron Homeostasis in Roots.
  3. ALS3 and NAP3 protein form an ABC transporter complex that is required for sugar-dependent response to phosphate deficiency.
    Title: An ABC transporter complex encoded by Aluminum Sensitive 3 and NAP3 is required for phosphate deficiency responses in Arabidopsis.
  4. The identification and expression of ALS3 gene, which encodes a transporter that is required for aluminum tolerance in Arabdiposis roots. [ALS3]
    Title: ALS3 encodes a phloem-localized ABC transporter-like protein that is required for aluminum tolerance in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_129289.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to aluminum ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aluminum sensitive 3
NP_181270.1
  • ALUMINUM SENSITIVE 3 (ALS3); CONTAINS InterPro DOMAIN/s: Conserved hypothetical protein CHP00245 (InterPro:IPR005226); Has 1906 Blast hits to 1906 proteins in 934 species: Archae - 39; Bacteria - 1722; Metazoa - 0; Fungi - 12; Plants - 43; Viruses - 0; Other Eukaryotes - 90 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    15669131..15670187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129289.5 → NP_181270.1  aluminum sensitive 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZUT3
    UniProtKB/TrEMBL
    A0A178VRI6, A0A5S9X4W9
    Conserved Domains (1) summary
    pfam03649
    Location:39 → 259
    UPF0014; Uncharacterized protein family (UPF0014)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZUT3.1

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