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URH1 uridine-ribohydrolase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818204, updated on 18-Sep-2024

Summary

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Official Symbol
URH1
Official Full Name
uridine-ribohydrolase 1
Primary source
TAIR:AT2G36310
Locus tag
AT2G36310
See related
Araport:AT2G36310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F2H17.8; F2H17_8; NSH1; nucleoside hydrolase 1; uridine-ribohydrolase 1
Summary
Encodes a cytoplasmic nucleoside hydrolase. It has the highest levels of activity with uridine followed by xanthosine. It shows little activity with inosine and none with cytidine. Mutant analyses indicate that it plays a role in purine and pyrimidine catabolism.
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Genomic context

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See URH1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (15224497..15227276, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene farnesylated protein-converting enzyme 2 Neighboring gene ncRNA Neighboring gene A20/AN1-like zinc finger family protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AMP and GMP Catabolism in Arabidopsis Converge on Xanthosine, Which Is Degraded by a Nucleoside Hydrolase Heterocomplex. Baccolini C, et al. Plant Cell, 2019 Mar. PMID 30787180, Free PMC Article
  2. Arabidopsis thaliana nucleosidase mutants provide new insights into nucleoside degradation. Riegler H, et al. New Phytol, 2011 Jul. PMID 21599668, Free PMC Article
  3. Uridine-ribohydrolase is a key regulator in the uridine degradation pathway of Arabidopsis. Jung B, et al. Plant Cell, 2009 Mar. PMID 19293370, Free PMC Article
  4. Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines. Jung B, et al. Plant J, 2011 Mar. PMID 21235647
  5. Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA. Gao S, et al. Nucleic Acids Res, 2023 Aug 11. PMID 37334828, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NSH1 activates NSH2 in vitro and in vivo, forming a complex with almost two orders of magnitude higher catalytic efficiency for xanthosine hydrolysis than observed for NSH1 alone. Remarkably, an inactive NSH1 point mutant can activate NSH2 in vivo, fully preventing purine nucleoside accumulation in nsh1 background.
    Title: AMP and GMP Catabolism in Arabidopsis Converge on Xanthosine, Which Is Degraded by a Nucleoside Hydrolase Heterocomplex.
  2. Both URH1 and URH2 are required for efficient inosine and xanthosine hydrolytic activity.
    Title: Arabidopsis thaliana nucleosidase mutants provide new insights into nucleoside degradation.
  3. Results describe the cloning of and characterization of Arabidopsis thaliana, Uridine-Ribohydrolase 1.
    Title: Uridine-ribohydrolase is a key regulator in the uridine degradation pathway of Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_129188.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables adenosine nucleosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables inosine nucleosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine nucleosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine nucleosidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables xanthosine nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within purine nucleoside catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within uridine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uridine-ribohydrolase 1
NP_565843.1
  • uridine-ribohydrolase 1 (URH1); CONTAINS InterPro DOMAIN/s: Inosine/uridine-preferring nucleoside hydrolase (InterPro:IPR001910); BEST Arabidopsis thaliana protein match is: uridine-ribohydrolase 2 (TAIR:AT1G05620.1); Has 6361 Blast hits to 6297 proteins in 1364 species: Archae - 75; Bacteria - 4675; Metazoa - 179; Fungi - 233; Plants - 187; Viruses - 0; Other Eukaryotes - 1012 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    15224497..15227276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129188.4 → NP_565843.1  uridine-ribohydrolase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q940Q6, Q9SJM7
    UniProtKB/TrEMBL
    A0A178VWR4, A0A5S9X4F7, A0A654F0S1
    Conserved Domains (1) summary
    PLN02717
    Location:22 → 336
    PLN02717; uridine nucleosidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SJM7.2

Gene LinkOut

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