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MMZ3 MMS ZWEI homologue 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818179, updated on 18-Sep-2024

Summary

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Official Symbol
MMZ3
Official Full Name
MMS ZWEI homologue 3
Primary source
TAIR:AT2G36060
Locus tag
AT2G36060
See related
Araport:AT2G36060
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F11F19.3; F11F19_3; MMS ZWEI homologue 3; UBIQUITIN E2 VARIANT 1C; UEV1C
Summary
MMZ3/UEV1C encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UEV1C can form diubiquitin and triubiquitin chains in combination with UBC13A/UBC35 in vitro. It can also functionally complement an mms2 mutation in budding yeast, both by increasing mms2 mutant viability in the presence of the DNA damaging agent MMS, and by reducing the rate of spontaneous DNA mutation. It can also rescue an mms2 ubc13 double mutant in yeast in combination with UBC13A. MMZ3/UEV1C transcripts are found at moderate levels in most plant organs, but cannot be detected in the pollen or 2 days after germination. Transcript levels do not appear to be stress-inducible.
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Genomic context

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See MMZ3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (15142653..15144221, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ovate family protein 15 Neighboring gene translocase inner membrane subunit 44-2 Neighboring gene AP2/B3-like transcriptional factor family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Wen R, et al. Plant Cell, 2008 Jan. PMID 18178771, Free PMC Article
  2. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
  3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

NM_001084542.1
NM_129165.4
NM_179928.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within postreplication repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of UBC13-MMS2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
MMS ZWEI homologue 3
NP_001078011.1
  • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.1); Has 2913 Blast hits to 2913 proteins in 284 species: Archae - 0; Bacteria - 0; Metazoa - 1555; Fungi - 342; Plants - 599; Viruses - 0; Other Eukaryotes - 417 (source: NCBI BLink).
NP_565834.1
  • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.1); Has 2912 Blast hits to 2912 proteins in 287 species: Archae - 0; Bacteria - 0; Metazoa - 1566; Fungi - 354; Plants - 579; Viruses - 0; Other Eukaryotes - 413 (source: NCBI BLink).
NP_850259.1
  • MMS ZWEI homologue 3 (MMZ3); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin E2 variant 1D-4 (TAIR:AT3G52560.2); Has 1347 Blast hits to 1347 proteins in 246 species: Archae - 0; Bacteria - 0; Metazoa - 655; Fungi - 163; Plants - 359; Viruses - 0; Other Eukaryotes - 170 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    15142653..15144221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129165.4 → NP_565834.1  MMS ZWEI homologue 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565834.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MQX2, Q3EBM3, Q9SJ44
    UniProtKB/TrEMBL
    A0A178VPH8, A0A5S9X4C4, A0A7G2EFT3
    Conserved Domains (1) summary
    smart00212
    Location:16 → 142
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  2. NM_001084542.1 → NP_001078011.1  MMS ZWEI homologue 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078011.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2EFT3
    Conserved Domains (1) summary
    smart00212
    Location:16 → 141
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

  3. NM_179928.2 → NP_850259.1  MMS ZWEI homologue 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850259.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VRN9, A0A7G2EFT3
    Conserved Domains (1) summary
    smart00212
    Location:16 → 143
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SJ44.1

Gene LinkOut

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