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Tpp2 tripeptidyl peptidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81815, updated on 27-Nov-2024

Summary

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Official Symbol
Tpp2provided by RGD
Official Full Name
tripeptidyl peptidase 2provided by RGD
Primary source
RGD:621584
See related
EnsemblRapid:ENSRNOG00000011194 AllianceGenome:RGD:621584
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TPP-2
Summary
Enables peptide binding activity and tripeptidyl-peptidase activity. Involved in protein catabolic process. Predicted to be located in nuclear body. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 247.0), Spleen (RPKM 243.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tpp2 in Genome Data Viewer
Location:
9q22
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53538788..53620253)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46046712..46128157)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50578868..50628943) , (50664048..50744803)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ECRG4 augurin precursor Neighboring gene mitochondrial ribosomal protein L30, pseudogene 7 Neighboring gene U6 spliceosomal RNA Neighboring gene methyltransferase 21C, AARS1 lysine Neighboring gene DnaJ heat shock protein family (Hsp40) member C14, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. [The changes in the activity of tripeptidyl peptidase II in experimental atherosclerosis and hypertension]. Pashevin DO, et al. Fiziol Zh (1994), 2014. PMID 25095668
  2. Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis. Wray CJ, et al. Biochem Biophys Res Commun, 2002 Aug 9. PMID 12147224
  3. The structure of human tripeptidyl peptidase II as determined by a hybrid approach. Schönegge AM, et al. Structure, 2012 Apr 4. PMID 22483107
  4. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Rose C, et al. Nature, 1996 Apr 4. PMID 8602240
  5. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. Beninga J, et al. J Biol Chem, 1998 Jul 24. PMID 9668046

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Changes in the activity of TPP II play an important role in the pathogenesis of blood vessels wall in atherosclerosis and arterial hypertension.
    Title: [The changes in the activity of tripeptidyl peptidase II in experimental atherosclerosis and hypertension].
  2. increase of expression and activity in skeletal muscle during sepsis
    Title: Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables aminopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables tripeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tripeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tripeptidyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular amino acid homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tripeptidyl-peptidase 2
Names
TPP-II
tripeptidyl aminopeptidase
tripeptidyl-peptidase II
NP_112399.1
XP_006244914.2
XP_006244915.2
XP_063123843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031137.2 → NP_112399.1  tripeptidyl-peptidase 2

    See identical proteins and their annotated locations for NP_112399.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q64560
    UniProtKB/TrEMBL
    A0A8L2R9L9, A6INR9
    Conserved Domains (2) summary
    cd04857
    Location:14 → 489
    Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
    pfam12580
    Location:777 → 963
    TPPII; Tripeptidyl peptidase II

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    53538788..53620253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244852.5 → XP_006244914.2  tripeptidyl-peptidase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R9L9, A6INR8
    Related
    ENSRNOP00000015393.5, ENSRNOT00000015393.7
    Conserved Domains (2) summary
    cd04857
    Location:14 → 489
    Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
    pfam12580
    Location:777 → 963
    TPPII; Tripeptidyl peptidase II

  2. XM_006244853.5 → XP_006244915.2  tripeptidyl-peptidase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R9L9

  3. XM_063267773.1 → XP_063123843.1  tripeptidyl-peptidase 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64560.3 GenPept UniProtKB/Swiss-Prot:Q64560

Gene LinkOut

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