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GlcNAc1pUT2 N-acetylglucosamine-1-phosphate uridylyltransferase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818066, updated on 14-Nov-2024

Summary

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Official Symbol
GlcNAc1pUT2
Official Full Name
N-acetylglucosamine-1-phosphate uridylyltransferase 2
Primary source
TAIR:AT2G35020
Locus tag
AT2G35020
See related
Araport:AT2G35020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F19I3.25; F19I3_25; GLCNA.UT2; N-acetylglucosamine-1-phosphate uridylyltransferase 2
Summary
Encodes a protein that functions as an N-acetylglucosamine-1-phosphate uridylyltransferase that catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc). This is an essential precursor for glycolipid and glycoprotein synthesis and is also used for regulatory protein modification in signaling pathways. The enzyme can also catalyze the reverse reaction using both UDP-GlcNAc and the less common UDP-N-acetylgalactosamine as substrates. This enzyme can also act on glucose-1-phosphate to produce UDP-glucose.
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Genomic context

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See GlcNAc1pUT2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
15
Sequence:
Chromosome: 2; NC_003071.7 (14756511..14760709)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene thioredoxin O1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene urease accessory protein D

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N-acetylglucosamine-1-P uridylyltransferase 1 and 2 are required for gametogenesis and embryo development in Arabidopsis thaliana. Chen YH, et al. Plant Cell Physiol, 2014 Nov. PMID 25231969
  2. Identification and characterization of a strict and a promiscuous N-acetylglucosamine-1-P uridylyltransferase in Arabidopsis. Yang T, et al. Biochem J, 2010 Sep 1. PMID 20557289
  3. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. At2g35020 is required for gametogenesis and embryo development in Arabidopsis thaliana.
    Title: N-acetylglucosamine-1-P uridylyltransferase 1 and 2 are required for gametogenesis and embryo development in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_129054.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables UDP-N-acetylgalactosamine diphosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylglucosamine diphosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within UDP-N-acetylgalactosamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-N-acetylglucosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within UDP-N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within UDP-alpha-D-glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo sac development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
N-acetylglucosamine-1-phosphate uridylyltransferase 2
NP_181047.1
  • N-acetylglucosamine-1-phosphate uridylyltransferase 2 (GlcNAc1pUT2); CONTAINS InterPro DOMAIN/s: UTP--glucose-1-phosphate uridylyltransferase (InterPro:IPR002618); BEST Arabidopsis thaliana protein match is: N-acetylglucosamine-1-phosphate uridylyltransferase 1 (TAIR:AT1G31070.2); Has 1547 Blast hits to 1541 proteins in 446 species: Archae - 0; Bacteria - 380; Metazoa - 421; Fungi - 279; Plants - 232; Viruses - 0; Other Eukaryotes - 235 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    14756511..14760709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129054.4 → NP_181047.1  N-acetylglucosamine-1-phosphate uridylyltransferase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181047.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64765, Q5PNR7, Q8L9P4
    UniProtKB/TrEMBL
    A0A178VSP9, A0A5S9X406
    Conserved Domains (1) summary
    PLN02435
    Location:1 → 502
    PLN02435; probable UDP-N-acetylglucosamine pyrophosphorylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O64765.1

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