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AGO6 Argonaute family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817856, updated on 18-Sep-2024

Summary

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Official Symbol
AGO6
Official Full Name
Argonaute family protein
Primary source
TAIR:AT2G32940
Locus tag
AT2G32940
See related
Araport:AT2G32940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARGONAUTE 6; T21L14.12; T21L14_12
Summary
Encodes a nuclear localized 879-amino-acid protein that contains conserved PAZ and PIWI domains that is important for the accumulation of specific heterochromatin-related siRNAs, and for DNA methylation and transcriptional gene silencing.
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Genomic context

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See AGO6 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
23
Sequence:
Chromosome: 2; NC_003071.7 (13971916..13977521, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene PDI-like 2-3 Neighboring gene zinc finger nuclease 2 Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene Phosphotyrosine protein phosphatases superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation. McCue AD, et al. EMBO J, 2015 Jan 2. PMID 25388951, Free PMC Article
  2. AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana. Eun C, et al. PLoS One, 2011. PMID 21998686, Free PMC Article
  3. Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing. Zheng X, et al. EMBO J, 2007 Mar 21. PMID 17332757, Free PMC Article
  4. The mechanisms of siRNA selection by plant Argonaute proteins triggering DNA methylation. Liu W, et al. Nucleic Acids Res, 2022 Dec 9. PMID 36477368, Free PMC Article
  5. The canonical RdDM pathway mediates the control of seed germination timing under salinity. Palomar VM, et al. Plant J, 2021 Feb. PMID 33131171

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mechanisms of siRNA selection by plant Argonaute proteins triggering DNA methylation.
    Title: The mechanisms of siRNA selection by plant Argonaute proteins triggering DNA methylation.
  2. The canonical RdDM pathway mediates the control of seed germination timing under salinity.
    Title: The canonical RdDM pathway mediates the control of seed germination timing under salinity.
  3. AGO4 and AGO6 mainly act sequentially in mediating small RNA-directed DNA methylation.
    Title: Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation.
  4. ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation.
    Title: ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation.
  5. the identification of the related AGO6 in a forward genetic screen for mutants defective in RNA-directed DNA methylation and transcriptional gene silencing in shoot and root apical meristems in Arabidopsis thaliana
    Title: AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana.
  6. AGO6 is important for the accumulation of specific heterochromatin-related siRNAs, and for DNA methylation and transcriptional gene silencing, this function is partly redundant with AGO4. [AGO6]
    Title: Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing.
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General gene information

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NM_128854.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables siRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within siRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Argonaute family protein
NP_180853.2
  • ARGONAUTE 6 (AGO6); CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), Argonaute/Dicer protein, PAZ (InterPro:IPR003100); BEST Arabidopsis thaliana protein match is: Argonaute family protein (TAIR:AT5G21150.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    13971916..13977521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128854.4 → NP_180853.2  Argonaute family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180853.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O48771
    UniProtKB/TrEMBL
    A0A178VS53, A0A654EZS0
    Conserved Domains (1) summary
    PLN03202
    Location:15 → 878
    PLN03202; protein argonaute; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O48771.2

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