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C4H cinnamate-4-hydroxylase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817599, updated on 18-Sep-2024

Summary

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Official Symbol
C4H
Official Full Name
cinnamate-4-hydroxylase
Primary source
TAIR:AT2G30490
Locus tag
AT2G30490
See related
Araport:AT2G30490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATC4H; CINNAMATE 4-HYDROXYLASE; cinnamate-4-hydroxylase; CINNAMATE-4-HYDROXYLASE; CYP73A5; REDUCED EPRDERMAL FLUORESCENCE 3; REF3; T6B20.16; T6B20_16
Summary
Encodes a cinnamate-4-hydroxylase. Mutations in this gene impact phenylpropanoid metabolism, growth and development.
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Genomic context

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See C4H in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (12993625..12996012, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene B3 domain-containing transcription repressor VAL1 Neighboring gene uncharacterized protein Neighboring gene Kinase interacting (KIP1-like) family protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene Phototropic-responsive NPH3 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatio-temporal control of phenylpropanoid biosynthesis by inducible complementation of a cinnamate 4-hydroxylase mutant. Kim JI, et al. J Exp Bot, 2021 Apr 2. PMID 33585900
  2. Cinnamate-4-hydroxylase expression in Arabidopsis. Regulation in response to development and the environment. Bell-Lelong DA, et al. Plant Physiol, 1997 Mar. PMID 9085570, Free PMC Article
  3. Isolation of a cDNA and a genomic clone encoding cinnamate 4-hydroxylase from Arabidopsis and its expression manner in planta. Mizutani M, et al. Plant Physiol, 1997 Mar. PMID 9085571, Free PMC Article
  4. Mutations in the cinnamate 4-hydroxylase gene impact metabolism, growth and development in Arabidopsis. Schilmiller AL, et al. Plant J, 2009 Dec. PMID 19682296
  5. Chemical Genetics Uncovers Novel Inhibitors of Lignification, Including p-Iodobenzoic Acid Targeting CINNAMATE-4-HYDROXYLASE. Van de Wouwer D, et al. Plant Physiol, 2016 Sep. PMID 27485881, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spatio-temporal control of phenylpropanoid biosynthesis by inducible complementation of a cinnamate 4-hydroxylase mutant.
    Title: Spatio-temporal control of phenylpropanoid biosynthesis by inducible complementation of a cinnamate 4-hydroxylase mutant.
  2. Data indicate that p-iodobenzoic acid was characterized as a new inhibitor of CINNAMATE 4-HYDROXYLASE, a key enzyme of the phenylpropanoid pathway synthesizing the building blocks of the lignin polymer.
    Title: Chemical Genetics Uncovers Novel Inhibitors of Lignification, Including p-Iodobenzoic Acid Targeting CINNAMATE-4-HYDROXYLASE.
  3. CYP73A5 and CYP98A3, the two Arabidopsis cytochrome P450s (P450s) catalyzing para- and meta-hydroxylations of the phenolic ring of monolignols were found to colocalize in the endoplasmic reticulum (ER) and to form homo- and heteromers.
    Title: Protein-protein and protein-membrane associations in the lignin pathway.
  4. C4H function is critical to normal development of Arabidopsis.
    Title: Mutations in the cinnamate 4-hydroxylase gene impact metabolism, growth and development in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_128601.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables trans-cinnamate 4-monooxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within developmental process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lignin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phenylpropanoid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within phenylpropanoid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pollen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in peroxisome HDA PubMed 
located_in plant-type cell wall HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 

General protein information

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Preferred Names
cinnamate-4-hydroxylase
NP_180607.1
  • cinnamate-4-hydroxylase (C4H); FUNCTIONS IN: trans-cinnamate 4-monooxygenase activity; INVOLVED IN: in 9 processes; LOCATED IN: endoplasmic reticulum, plasma membrane, membrane, plant-type cell wall; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 98, subfamily A, polypeptide 3 (TAIR:AT2G40890.1); Has 31278 Blast hits to 31002 proteins in 1609 species: Archae - 48; Bacteria - 2734; Metazoa - 11804; Fungi - 6596; Plants - 9113; Viruses - 3; Other Eukaryotes - 980 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    12993625..12996012 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128601.3 → NP_180607.1  cinnamate-4-hydroxylase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180607.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04995, O49834, P92993, P92994
    UniProtKB/TrEMBL
    A0A178VRU1, B1GV39, B1GV49
    Conserved Domains (1) summary
    PLN02394
    Location:3 → 505
    PLN02394; trans-cinnamate 4-monooxygenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P92994.1

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