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KIS tubulin folding cofactor A (KIESEL) [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817592, updated on 18-Sep-2024

Summary

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Official Symbol
KIS
Official Full Name
tubulin folding cofactor A (KIESEL)
Primary source
TAIR:AT2G30410
Locus tag
AT2G30410
See related
Araport:AT2G30410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
KIESEL; T9D9.22; T9D9_22; TFCA; TUBULIN FOLDING FACTOR A
Summary
mutant has embryo defect; enlarged embryo cells and endosperm nuclei; Tubulin Folding Cofactor A
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Genomic context

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See KIS in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Sequence:
Chromosome: 2; NC_003071.7 (12958116..12960768)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ovate family protein 17 Neighboring gene ovate family protein 2 Neighboring gene ncRNA Neighboring gene Homeodomain-like superfamily protein Neighboring gene Homeodomain-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallization and preliminary X-ray analysis of tubulin-folding cofactor A from Arabidopsis thaliana. Lu L, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Aug 1. PMID 20693679, Free PMC Article
  2. The Arabidopsis TUBULIN-FOLDING COFACTOR A gene is involved in the control of the alpha/beta-tubulin monomer balance. Kirik V, et al. Plant Cell, 2002 Sep. PMID 12215519, Free PMC Article
  3. Crystal structure of tubulin folding cofactor A from Arabidopsis thaliana and its beta-tubulin binding characterization. Lu L, et al. FEBS Lett, 2010 Aug 20. PMID 20638386
  4. The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Steinborn K, et al. Genes Dev, 2002 Apr 15. PMID 11959844, Free PMC Article
  5. Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana. Dortay H, et al. J Proteome Res, 2008 Sep. PMID 18642946

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001202711.2
NM_128594.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cytokinesis by cell plate formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in post-chaperonin tubulin folding pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in tubulin complex assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tubulin complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in peroxisome HDA PubMed 

General protein information

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Preferred Names
tubulin folding cofactor A (KIESEL)
NP_001189640.1
  • KIESEL (KIS); FUNCTIONS IN: unfolded protein binding; INVOLVED IN: tubulin complex assembly, cytokinesis; LOCATED IN: microtubule; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tubulin binding cofactor A (InterPro:IPR004226).
NP_001318319.1
  • KIESEL (KIS); FUNCTIONS IN: unfolded protein binding; INVOLVED IN: tubulin complex assembly, cytokinesis; LOCATED IN: microtubule; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tubulin binding cofactor A (InterPro:IPR004226); Has 359 Blast hits to 359 proteins in 168 species: Archae - 0; Bacteria - 0; Metazoa - 159; Fungi - 92; Plants - 60; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    12958116..12960768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336255.1 → NP_001318319.1  tubulin folding cofactor A (KIESEL) [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04350, Q547H3, Q949R2
    UniProtKB/TrEMBL
    A0A178VY81, A0A5S9X2M7, A0A7G2EC90
    Conserved Domains (1) summary
    pfam02970
    Location:7 → 90
    TBCA; Tubulin binding cofactor A

  2. NM_001202711.2 → NP_001189640.1  tubulin folding cofactor A (KIESEL) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04350, Q547H3, Q949R2
    UniProtKB/TrEMBL
    A0A178VY81, A0A5S9X2M7, A0A7G2EC90
    Conserved Domains (1) summary
    pfam02970
    Location:7 → 90
    TBCA; Tubulin binding cofactor A

  3. NM_128594.4 → NP_565699.1  tubulin folding cofactor A (KIESEL) [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565699.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O04350, Q547H3, Q949R2
    UniProtKB/TrEMBL
    A0A178VY81, A0A5S9X2M7, A0A7G2EC90
    Conserved Domains (1) summary
    pfam02970
    Location:7 → 90
    TBCA; Tubulin binding cofactor A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O04350.2

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