FC2 ferrochelatase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: FC2
Official Full Name: ferrochelatase 2
Primary source: TAIR:AT2G30390
Locus tag: AT2G30390
See related: Araport:AT2G30390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATFC-II; FC-II; ferrochelatase 2; T9D9.1
Summary: Encodes one of two ferrochelatase genes in Arabidopsis. Ferrochelatase is the terminal enzyme of heme biosynthesis. FC-II is speculated to operate in photosynthetic cytochromes
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See FC2 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 10

Sequence:: Chromosome: 2; NC_003071.7 (12950954..12954148, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway.
Title: FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway.
Singlet Oxygen Leads to Structural Changes to Chloroplasts during their Degradation in the Arabidopsis thaliana plastid ferrochelatase two Mutant.
Title: Singlet Oxygen Leads to Structural Changes to Chloroplasts during their Degradation in the Arabidopsis thaliana plastid ferrochelatase two Mutant.
When frataxin is combined with AtNFS1 and AtISD11 the ferrochelatse activity is increased. These results suggest that frataxin could be the iron donor in the final step of heme synthesis in plant mitochondria, and constitutes an important advance in the elucidation of the mechanisms of heme synthesis in plants.
Title: Ferrochelatase activity of plant frataxin.
FC2 produces heme not only for photosynthetic cytochromes, but also for proteins involved in stress responses, whereas the impairment of FC1 apparently interferes only marginally with stress responses.
Title: Functional characterization of the two ferrochelatases in Arabidopsis thaliana.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001202710.1

Supported by ESTs:

NM_128592.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ferrochelatase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in porphyrin-containing compound biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tetrapyrrole biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in peroxisome	HDA more info	PubMed
located_in plastid thylakoid membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ferrochelatase 2

NP_001189639.1

ferrochelatase 2 (FC2); FUNCTIONS IN: ferrochelatase activity; INVOLVED IN: heme biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferrochelatase (InterPro:IPR001015), Ferrochelatase, active site (InterPro:IPR019772); BEST Arabidopsis thaliana protein match is: ferrochelatase 1 (TAIR:AT5G26030.2).

NP_180598.1

ferrochelatase 2 (FC2); FUNCTIONS IN: ferrochelatase activity; INVOLVED IN: heme biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferrochelatase, active site (InterPro:IPR019772), Ferrochelatase (InterPro:IPR001015); BEST Arabidopsis thaliana protein match is: ferrochelatase 1 (TAIR:AT5G26030.2); Has 7540 Blast hits to 7536 proteins in 2081 species: Archae - 19; Bacteria - 4228; Metazoa - 173; Fungi - 140; Plants - 125; Viruses - 0; Other Eukaryotes - 2855 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12950954..12954148 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128592.3 → NP_180598.1 ferrochelatase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180598.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04921, O23623, Q7GB39

UniProtKB/TrEMBL

A0A178VU64, A0A5S9X2U0, A0A7G2EG32

Conserved Domains (1) summary

PLN02449
Location:30 → 505

PLN02449; ferrochelatase
NM_001202710.1 → NP_001189639.1 ferrochelatase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001189639.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2EG32, F4IMT3

Conserved Domains (3) summary

PLN02449
Location:30 → 515

PLN02449; ferrochelatase

cd00419
Location:269 → 417

Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...

cd03411
Location:101 → 263

Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...