SIP4 SOS3-interacting protein 4 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SIP4
Official Full Name: SOS3-interacting protein 4
Primary source: TAIR:AT2G30360
Locus tag: AT2G30360
See related: Araport:AT2G30360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CBL-INTERACTING PROTEIN KINASE 11; CIPK11; PKS5; PROTEIN KINASE SOS2-LIKE 5; SNF1-RELATED PROTEIN KINASE 3.22; SNRK3.22; SOS3-interacting protein 4; T9D9.17; T9D9_17
Summary: Encodes a SOS2-like protein kinase that is a member of the CBL-interacting protein kinase family.Loss of function mutants show a decrease in sensitivity to high pH.Phosphorylates AHA2, a plasma membrane H+ ATPase.This phosphorylation appears to regulate the activity of the proton transporter.
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Genomic context

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See SIP4 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (12936968..12938834, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The kinase CIPK11 functions as a positive regulator in cadmium stress response in Arabidopsis.
Title: The kinase CIPK11 functions as a positive regulator in cadmium stress response in Arabidopsis.
The overexpression of CIPK11 (CIPK11OE) in Arabidopsis resulted in the decreased tolerance of plant to drought stress. CIPK11 partly mediates the drought stress response by regulating the transcription factor Di19-3.
Title: The Kinase CIPK11 Functions as a Negative Regulator in Drought Stress Response in Arabidopsis.
propose that Ca(2+)-triggered CBL1/9-mediated activation of CIPK11 and subsequent phosphorylation of FIT shifts inactive into active FIT, allowing regulatory protein interactions in the nucleus
Title: CIPK11-Dependent Phosphorylation Modulates FIT Activity to Promote Arabidopsis Iron Acquisition in Response to Calcium Signaling.
SOS2-LIKE PROTEIN KINASE5 (PKS5) can negatively regulate the Salt-Overly-Sensitive signaling pathway in Arabidopsis. PKS5 can interact with and phosphorylate SOS2 at Ser294, promote the interaction between SOS2 and 14-3-3 proteins, and repress SOS2 activity. However, salt stress promotes an interaction between 14-3-3 proteins and PKS5, repressing its kinase activity and releasing inhibition of SOS2.
Title: Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance.
PKS5-mediated phosphorylation of ABI5 at Ser-42 is critical for the abscissic acid regulation of seed germination and gene expression in Arabidopsis.
Title: SOS2-LIKE PROTEIN KINASE5, an SNF1-RELATED PROTEIN KINASE3-Type Protein Kinase, Is Important for Abscisic Acid Responses in Arabidopsis through Phosphorylation of ABSCISIC ACID-INSENSITIVE5.
PKS5 involves in external high pH signal mediated microfilament depolymerization, and that may be independent of calcium signal.
Title: The alkaline tolerance in Arabidopsis requires stabilizing microfilament partially through inactivation of PKS5 kinase.
results suggest that PKS5 functions at the upstream of NPR1 and might mediate expression of WRKY38 and WRKY62 possibly by interacting with and phosphorylating NPR1.
Title: PKS5, a SNF1-related kinase, interacts with and phosphorylates NPR1, and modulates expression of WRKY38 and WRKY62.
J3 regulates plasma membrane H+-ATPase activity through interaction with the PKS5 kinase.
Title: The Arabidopsis chaperone J3 regulates the plasma membrane H+-ATPase through interaction with the PKS5 kinase.
These results suggest that PKS5 is part of a calcium-signaling pathway mediating PM H+ -ATPase regulation.
Title: Arabidopsis protein kinase PKS5 inhibits the plasma membrane H+ -ATPase by preventing interaction with 14-3-3 protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128589.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in abscisic acid-activated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within abscisic acid-activated signaling pathway	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SOS3-interacting protein 4

NP_180595.1

SOS3-interacting protein 4 (SIP4); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), NAF domain (InterPro:IPR004041), CBL-interacting protein kinase (InterPro:IPR020660), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: serine/threonine protein kinase 1 (TAIR:AT5G01820.1); Has 132389 Blast hits to 130226 proteins in 4650 species: Archae - 184; Bacteria - 15582; Metazoa - 48520; Fungi - 13393; Plants - 32054; Viruses - 541; Other Eukaryotes - 22115 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12936968..12938834 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128589.2 → NP_180595.1 SOS3-interacting protein 4 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180595.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22932, Q7FYB7, Q944I6

UniProtKB/TrEMBL

A0A178W0H8, A0A5S9X2L0, A0A654F869

Conserved Domains (2) summary

cd12195
Location:308 → 421

CIPK_C; C-terminal regulatory domain of Calcineurin B-Like (CBL)-interacting protein kinases

cl21453
Location:20 → 276

PKc_like; Protein Kinases, catalytic domain