U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

VLN1 villin-like 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817539, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
VLN1
Official Full Name
villin-like 1
Primary source
TAIR:AT2G29890
Locus tag
AT2G29890
See related
Araport:AT2G29890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATVLN1; F6K5.2; F6K5_2; villin 1; villin-like 1
Summary
Encodes a ubiquitously expressed villin-like protein, whose mRNA may be alternatively processed. Villin belongs to a superfamily of actin binding proteins called the villin/gelsolin family. Animal villins are involved in actin binding. VLN1 protein co-localizes with actin filaments in several assays. VLN1 binds and bundles F-actin in a calcium-independent manner. It does not nucleate, cap or sever actin filaments and it stabilizes actin filaments, protecting them from ADF-mediated depolymerization.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See VLN1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
23
Sequence:
Chromosome: 2; NC_003071.7 (12744116..12749596)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Aquaporin-like superfamily protein Neighboring gene Myb/SANT-like DNA-binding domain protein Neighboring gene Presenilin-2 Neighboring gene F-box/RNI-like superfamily protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Villin-like actin-binding proteins are expressed ubiquitously in Arabidopsis. Klahre U, et al. Plant Physiol, 2000 Jan. PMID 10631247, Free PMC Article
  2. Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover. Khurana P, et al. Plant Cell, 2010 Aug. PMID 20807878, Free PMC Article
  3. Arabidopsis VILLIN1 generates actin filament cables that are resistant to depolymerization. Huang S, et al. Plant Cell, 2005 Feb. PMID 15659626, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VLN1 does not protect individual actin filaments from severing by VLN3.
    Title: Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_001036367.2
NM_001202706.1
NM_001336228.1
NM_128543.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
NOT involved_in actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within actin filament organization IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in actin filament severing IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in actin nucleation IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in barbed-end actin filament capping IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
villin-like 1
NP_001031444.2
  • villin-like 1 (VLN1); CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin 4 (TAIR:AT4G30160.1); Has 3163 Blast hits to 1761 proteins in 187 species: Archae - 0; Bacteria - 6; Metazoa - 2500; Fungi - 105; Plants - 222; Viruses - 0; Other Eukaryotes - 330 (source: NCBI BLink).
NP_001189635.1
  • villin-like 1 (VLN1); CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin 4 (TAIR:AT4G30160.1).
NP_029567.1
  • villin-like 1 (VLN1); CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin 4 (TAIR:AT4G30160.1); Has 3095 Blast hits to 1746 proteins in 186 species: Archae - 0; Bacteria - 6; Metazoa - 2441; Fungi - 102; Plants - 219; Viruses - 0; Other Eukaryotes - 327 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    12744116..12749596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336227.1 → NP_001324174.1  villin-like 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AZB7, A0A5S9X2Q0

  2. NM_128543.4 → NP_029567.1  villin-like 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_029567.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81643, O82367, Q9SIK8
    UniProtKB/TrEMBL
    A0A5S9X2Q0
    Conserved Domains (7) summary
    smart00153
    Location:874 → 909
    VHP; Villin headpiece domain
    cd11288
    Location:514 → 605
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:140 → 231
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:12 → 123
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:618 → 715
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:245 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:383 → 483
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  3. NM_001202706.1 → NP_001189635.1  villin-like 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189635.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9X2Q0, F4ILN8
    Conserved Domains (7) summary
    smart00153
    Location:898 → 933
    VHP; Villin headpiece domain
    cd11288
    Location:514 → 605
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:140 → 231
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:12 → 123
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:618 → 717
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:245 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:383 → 483
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  4. NM_001036367.2 → NP_001031444.2  villin-like 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031444.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9X2Q0, Q2V445
    Conserved Domains (7) summary
    smart00153
    Location:876 → 911
    VHP; Villin headpiece domain
    cd11288
    Location:514 → 605
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:140 → 231
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:12 → 123
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:618 → 717
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:245 → 344
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:383 → 483
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  5. NM_001336228.1 → NP_001324173.1  villin-like 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81643, O82367, Q9SIK8
    UniProtKB/TrEMBL
    A0A5S9X2Q0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O81643.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.