TOPP1 type one protein phosphatase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TOPP1
Official Full Name: type one protein phosphatase 1
Primary source: TAIR:AT2G29400
Locus tag: AT2G29400
See related: Araport:AT2G29400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: PP1-AT; PROTEIN PHOSPHATASE 1; type one protein phosphatase 1
Summary: Type 1 protein phosphatase, expressed in roots, rosettes and flowers
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Genomic context

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See TOPP1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 4

Sequence:: Chromosome: 2; NC_003071.7 (12613014..12615414, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, our results uncover TOPP1 and AtI-2 as negative regulators of ABA signaling.
Title: Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128494.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein dephosphorylation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
part_of protein phosphatase type 1 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: type one protein phosphatase 1

NP_180501.1

type one protein phosphatase 1 (TOPP1); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: type one serine/threonine protein phosphatase 2 (TAIR:AT5G59160.3); Has 7268 Blast hits to 7072 proteins in 663 species: Archae - 78; Bacteria - 610; Metazoa - 2414; Fungi - 1413; Plants - 987; Viruses - 22; Other Eukaryotes - 1744 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

12613014..12615414 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128494.5 → NP_180501.1 type one protein phosphatase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180501.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P30366

UniProtKB/TrEMBL

A0A178VXL8, A0A5S9X295

Conserved Domains (1) summary

cd07414
Location:19 → 310

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain