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CYP707A2 cytochrome P450, family 707, subfamily A, polypeptide 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817457, updated on 18-Sep-2024

Summary

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Official Symbol
CYP707A2
Official Full Name
cytochrome P450, family 707, subfamily A, polypeptide 2
Primary source
TAIR:AT2G29090
Locus tag
AT2G29090
See related
Araport:AT2G29090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
''cytochrome P450; cytochrome P450; family 707; polypeptide 2; polypeptide 2''; subfamily A; T9I4.17; T9I4_17
Summary
Encodes a protein with ABA 8'-hydroxylase activity, involved in ABA catabolism. Member of the CYP707A gene family. This gene predominantly accumulates in dry seeds and is up-regulated immediately following imbibition. CYP707A2 appears to play a major role in the rapid decrease in ABA levels during early seed imbibition.
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Genomic context

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See CYP707A2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (12494826..12499723, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Ubiquitin fusion degradation UFD1 family protein Neighboring gene FTSH protease 3 Neighboring gene ncRNA Neighboring gene glutamate receptor 2.9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of the abscisic acid catabolic gene CYP707A2 in the glucose-induced delay in seed germination and post-germination growth of Arabidopsis. Zhu G, et al. Physiol Plant, 2011 Dec. PMID 21883251
  2. The Arabidopsis abscisic acid catabolic gene CYP707A2 plays a key role in nitrate control of seed dormancy. Matakiadis T, et al. Plant Physiol, 2009 Feb. PMID 19074630, Free PMC Article
  3. The Arabidopsis cytochrome P450 CYP707A encodes ABA 8'-hydroxylases: key enzymes in ABA catabolism. Kushiro T, et al. EMBO J, 2004 Apr 7. PMID 15044947, Free PMC Article
  4. NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis. Yan D, et al. Nat Commun, 2016 Oct 12. PMID 27731416, Free PMC Article
  5. CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis. Okamoto M, et al. Plant Physiol, 2006 May. PMID 16543410, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic analysis shows that NLP8-mediated promotion of seed germination by nitrate requires CYP707A2.
    Title: NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis.
  2. Glucose-induced delay in seed germination and seedling development is directly related to the suppression of ABA catabolism through the repression of the CYP707A2 expression.
    Title: Involvement of the abscisic acid catabolic gene CYP707A2 in the glucose-induced delay in seed germination and post-germination growth of Arabidopsis.
  3. central role of the CYP707A2 gene in the nitrate-mediated control of Abscisic acid levels during seed development and germination of arabidopsis thaliana.
    Title: The Arabidopsis abscisic acid catabolic gene CYP707A2 plays a key role in nitrate control of seed dormancy.
  4. CYP707A2 transcript levels increase from late-maturation to mature dry seed and plays a distinct role in seed development and postgermination growth.
    Title: CYP707A1 and CYP707A2, which encode abscisic acid 8'-hydroxylases, are indispensable for proper control of seed dormancy and germination in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001202700.1
NM_001336198.1
NM_001336199.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
NOT enables (+)-abscisic acid 8'-hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (+)-abscisic acid 8'-hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within release of seed from dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to red light IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to red or far red light IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
cytochrome P450, family 707, subfamily A, polypeptide 2
NP_001189629.1
  • ''cytochrome P450, family 707, subfamily A, polypeptide 2'' (CYP707A2); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 3 (TAIR:AT5G45340.1).
NP_180473.1
  • ''cytochrome P450, family 707, subfamily A, polypeptide 2'' (CYP707A2); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 7 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 3 (TAIR:AT5G45340.1); Has 36442 Blast hits to 36296 proteins in 1886 species: Archae - 82; Bacteria - 8337; Metazoa - 11529; Fungi - 6203; Plants - 8178; Viruses - 6; Other Eukaryotes - 2107 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    12494826..12499723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128466.4 → NP_180473.1  cytochrome P450, family 707, subfamily A, polypeptide 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180473.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81077
    UniProtKB/TrEMBL
    A0A5S9X2D0, A0A654EY99
    Conserved Domains (1) summary
    cl12078
    Location:45 → 477
    p450; Cytochrome P450

  2. NM_001202700.1 → NP_001189629.1  cytochrome P450, family 707, subfamily A, polypeptide 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189629.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81077
    UniProtKB/TrEMBL
    A0A5S9X2D0, A0A654EY99
    Conserved Domains (1) summary
    cl12078
    Location:45 → 477
    p450; Cytochrome P450

  3. NM_001336198.1 → NP_001324571.1  cytochrome P450, family 707, subfamily A, polypeptide 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B0J6, A0A5S9X2D0, A0A654EY99

  4. NM_001336199.1 → NP_001324570.1  cytochrome P450, family 707, subfamily A, polypeptide 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B0N0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O81077.1

Gene LinkOut

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