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ftsh3 FTSH protease 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817456, updated on 18-Sep-2024

Summary

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Official Symbol
ftsh3
Official Full Name
FTSH protease 3
Primary source
TAIR:AT2G29080
Locus tag
AT2G29080
See related
Araport:AT2G29080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
FTSH protease 3; T9I4.16; T9I4_16
Summary
encodes an FtsH protease that is localized to the mitochondrion
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Genomic context

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See ftsh3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Sequence:
Chromosome: 2; NC_003071.7 (12489627..12493329, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene GRAS family transcription factor Neighboring gene Ubiquitin fusion degradation UFD1 family protein Neighboring gene cytochrome P450, family 707, subfamily A, polypeptide 2 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly. Ivanova A, et al. Plant Physiol, 2021 May 27. PMID 33616659, Free PMC Article
  2. Identification and characterization of high molecular weight complexes formed by matrix AAA proteases and prohibitins in mitochondria of Arabidopsis thaliana. Piechota J, et al. J Biol Chem, 2010 Apr 23. PMID 20172857, Free PMC Article
  3. Chloroplast and mitochondrial proteases in Arabidopsis. A proposed nomenclature. Adam Z, et al. Plant Physiol, 2001 Apr. PMID 11299370, Free PMC Article
  4. Coordinated regulation and complex formation of yellow variegated1 and yellow variegated2, chloroplastic FtsH metalloproteases involved in the repair cycle of photosystem II in Arabidopsis thylakoid membranes. Sakamoto W, et al. Plant Cell, 2003 Dec. PMID 14630971, Free PMC Article
  5. New functions of the thylakoid membrane proteome of Arabidopsis thaliana revealed by a simple, fast, and versatile fractionation strategy. Peltier JB, et al. J Biol Chem, 2004 Nov 19. PMID 15322131

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly.
    Title: The mitochondrial AAA protease FTSH3 regulates Complex I abundance by promoting its disassembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_179798.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast thylakoid membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
FTSH protease 3
NP_850129.1
  • FTSH protease 3 (ftsh3); FUNCTIONS IN: ATP-dependent peptidase activity, ATPase activity; INVOLVED IN: proteolysis, protein catabolic process; LOCATED IN: mitochondrion, chloroplast thylakoid membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M41, FtsH (InterPro:IPR005936), ATPase, AAA+ type, core (InterPro:IPR003593), ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA-type, conserved site (InterPro:IPR003960), Peptidase M41 (InterPro:IPR000642), Peptidase M41, FtsH extracellular (InterPro:IPR011546); BEST Arabidopsis thaliana protein match is: FTSH protease 10 (TAIR:AT1G07510.1); Has 42068 Blast hits to 39734 proteins in 3332 species: Archae - 1581; Bacteria - 17420; Metazoa - 4814; Fungi - 3774; Plants - 3280; Viruses - 30; Other Eukaryotes - 11169 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    12489627..12493329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179798.2 → NP_850129.1  FTSH protease 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850129.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81076, Q0WWR8, Q84WU8, Q8VZR5
    UniProtKB/TrEMBL
    A0A178VS82, A0A5S9X2R1, A0A654EX55
    Conserved Domains (2) summary
    TIGR01241
    Location:259 → 758
    FtsH_fam; ATP-dependent metalloprotease FtsH
    pfam06480
    Location:135 → 244
    FtsH_ext; FtsH Extracellular
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q84WU8.1

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