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RAD51B DNA repair (Rad51) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817404, updated on 18-Sep-2024

Summary

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Official Symbol
RAD51B
Official Full Name
DNA repair (Rad51) family protein
Primary source
TAIR:AT2G28560
Locus tag
AT2G28560
See related
Araport:AT2G28560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRAD51B; T17D12.12; T17D12_12
Summary
Encodes a protein of the RAD51B family involved in double stranded DNA repair. Homozygous mutant plants show increased sensitivity to mitomycin which induces DS breaks.
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Genomic context

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See RAD51B in Genome Data Viewer
Location:
chromosome: 2
Exon count:
14
Sequence:
Chromosome: 2; NC_003071.7 (12235875..12239146, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RNA binding (RRM/RBD/RNP motifs) family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transmembrane protein, putative (DUF247)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of XRCC2 and RAD51B mutations on somatic and meiotic recombination in Arabidopsis thaliana. Da Ines O, et al. Plant J, 2013 Jun. PMID 23521529
  2. Arabidopsis Rad51B is important for double-strand DNA breaks repair in somatic cells. Osakabe K, et al. Plant Mol Biol, 2005 Apr. PMID 15952068
  3. Roles of XRCC2, RAD51B and RAD51D in RAD51-independent SSA recombination. Serra H, et al. PLoS Genet, 2013 Nov. PMID 24278037, Free PMC Article
  4. Genome stability of Arabidopsis atm, ku80 and rad51b mutants: somatic and transgenerational responses to stress. Yao Y, et al. Plant Cell Physiol, 2013 Jun. PMID 23574700
  5. Differing requirements for the Arabidopsis Rad51 paralogs in meiosis and DNA repair. Bleuyard JY, et al. Plant J, 2005 Feb. PMID 15686518

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Notwithstanding their clearly established importance for RAD51-dependent homologous recombination, XRCC2, RAD51B and RAD51D thus also participate in Single-Strand Annealing recombination.
    Title: Roles of XRCC2, RAD51B and RAD51D in RAD51-independent SSA recombination.
  2. The genome stability of the Arabidopsis thaliana mutants deficient in ATM (communication between DNA strand break recognition and the repair machinery), KU80 (deficient in NHEJ) and RAD51B (deficient in HR repair) genes, was investigated.
    Title: Genome stability of Arabidopsis atm, ku80 and rad51b mutants: somatic and transgenerational responses to stress.
  3. The roles of RAD51B and XRCC2 in recombination are thus not limited to mitotic cells.
    Title: Effects of XRCC2 and RAD51B mutations on somatic and meiotic recombination in Arabidopsis thaliana.
  4. Results suggest that AtRAD51B gene product is involved in the repair of double-strand DNA breaks via homologous recombination. [Rad51B]
    Title: Arabidopsis Rad51B is important for double-strand DNA breaks repair in somatic cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036361.2
NM_001124931.1
NM_001161066.1
NM_128416.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA strand exchange activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Rad51B-Rad51C-Rad51D-XRCC2 complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DNA repair (Rad51) family protein
NP_001031438.1
  • RAD51B; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51C (TAIR:AT2G45280.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001118403.1
  • RAD51B; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51 (TAIR:AT5G20850.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_001154538.1
  • RAD51B; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: homolog of RAD51 D (TAIR:AT1G07745.2); Has 2570 Blast hits to 2570 proteins in 515 species: Archae - 541; Bacteria - 205; Metazoa - 686; Fungi - 429; Plants - 272; Viruses - 16; Other Eukaryotes - 421 (source: NCBI BLink).
NP_180423.3
  • RAD51B; CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), ATPase, AAA+ type, core (InterPro:IPR003593), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: RAS associated with diabetes protein 51C (TAIR:AT2G45280.2); Has 2717 Blast hits to 2715 proteins in 543 species: Archae - 539; Bacteria - 255; Metazoa - 717; Fungi - 449; Plants - 276; Viruses - 18; Other Eukaryotes - 463 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    12235875..12239146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336172.1 → NP_001323470.1  DNA repair (Rad51) family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5H793, Q5H794, Q5K4Q0, Q9SK02
    UniProtKB/TrEMBL
    A0A178VZL1, A0A5S9X2C0, A0A654EYF4
    Conserved Domains (1) summary
    cd19493
    Location:92 → 321
    Rad51B; RAD51B recombinase

  2. NM_001336173.1 → NP_001323469.1  DNA repair (Rad51) family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5H793, Q5H794, Q5K4Q0, Q9SK02
    UniProtKB/TrEMBL
    A0A178VZL1, A0A5S9X2C0, A0A654EYF4
    Conserved Domains (1) summary
    cd19493
    Location:92 → 321
    Rad51B; RAD51B recombinase

  3. NM_001036361.2 → NP_001031438.1  DNA repair (Rad51) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031438.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5H793, Q5H794, Q5K4Q0, Q9SK02
    UniProtKB/TrEMBL
    A0A178VZL1, A0A5S9X2C0, A0A654EYF4
    Conserved Domains (1) summary
    cd19493
    Location:92 → 321
    Rad51B; RAD51B recombinase

  4. NM_001124931.1 → NP_001118403.1  DNA repair (Rad51) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118403.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4IIR6, Q2VTQ5
    Conserved Domains (2) summary
    pfam08423
    Location:33 → 304
    Rad51; Rad51
    cl21455
    Location:52 → 305
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001161066.1 → NP_001154538.1  DNA repair (Rad51) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154538.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SK02
    Conserved Domains (2) summary
    COG0468
    Location:34 → 226
    RecA; RecA/RadA recombinase [Replication, recombination and repair]
    cl21455
    Location:52 → 240
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. NM_128416.4 → NP_180423.3  DNA repair (Rad51) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180423.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654EYF4
    Conserved Domains (2) summary
    pfam08423
    Location:65 → 336
    Rad51; Rad51
    cl21455
    Location:84 → 337
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SK02.2

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