PD1 prephenate dehydratase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PD1
Official Full Name: prephenate dehydratase 1
Primary source: TAIR:AT2G27820
Locus tag: AT2G27820
See related: Araport:AT2G27820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ADT3; arogenate dehydratase 3; F15K20.8; F15K20_8; prephenate dehydratase 1
Summary: Encodes a plastid-localized arogenate dehydratase involved in phenylalanine biosynthesis. Not less than six genes encoding ADT were identified in the Arabidopsis genome: ADT1 [At1g11790]; ADT2 [At3g07630]; ADT3 [At2g27820]; ADT4 [At3g44720]; ADT5 [At5g22630]; and ADT6 [At1g08250].
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Genomic context

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See PD1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (11856571..11858288)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plastid Deficient 1 Is Essential for the Accumulation of Plastid-Encoded RNA Polymerase Core Subunit beta and Chloroplast Development in Arabidopsis.
Title: Plastid Deficient 1 Is Essential for the Accumulation of Plastid-Encoded RNA Polymerase Core Subunit β and Chloroplast Development in Arabidopsis.
ADT3 role in photosynthesis and secondary metabolism.
Title: Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism.
Data show that loss of AROGENATE DEHYDRATASE3 (ADT3) disrupts cotyledon epidermal patterning by affecting the number and expansion of pavement cells and stomata cell fate specification.
Title: The Dehydratase ADT3 Affects ROS Homeostasis and Cotyledon Development.
G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 form all of or part of a signal transduction mechanism responsible for the light-mediated synthesis of phenylpyruvate and phenylalanine.
Title: G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_128342.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables arogenate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables prephenate dehydratase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-phenylalanine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to low fluence blue light stimulus by blue low-fluence system	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tyrosine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: prephenate dehydratase 1

NP_180350.1

prephenate dehydratase 1 (PD1); CONTAINS InterPro DOMAIN/s: Prephenate dehydratase (InterPro:IPR001086), Prephenate dehydratase, conserved site (InterPro:IPR018528); BEST Arabidopsis thaliana protein match is: arogenate dehydratase 6 (TAIR:AT1G08250.1); Has 7147 Blast hits to 7145 proteins in 2247 species: Archae - 179; Bacteria - 4014; Metazoa - 4; Fungi - 119; Plants - 265; Viruses - 0; Other Eukaryotes - 2566 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

11856571..11858288

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128342.3 → NP_180350.1 prephenate dehydratase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180350.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WNL3, Q8LAP1, Q9ZUY3

UniProtKB/TrEMBL

A0A178VVA2

Conserved Domains (3) summary

cd04905
Location:311 → 404

ACT_CM-PDT; C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme

PLN02317
Location:17 → 408

PLN02317; arogenate dehydratase

cd13631
Location:120 → 301

PBP2_Ct-PDT_like; Catalytic domain of prephenate dehydratase from Chlorobium tepidum and similar proteins, subgroup 2; the type 2 periplasmic binding protein fold